A530032D15Rik Inhibitors
Chemical inhibitors of Sp140 nuclear body protein like 1 target the modulation of chromatin structure and function through various mechanisms. Trichostatin A and SAHA (Vorinostat) are inhibitors that work by obstructing histone deacetylases (HDACs), enzymes responsible for the removal of acetyl groups from histone proteins. This inhibition can lead to a more open chromatin structure, affecting DNA accessibility and gene expression. As Sp140 nuclear body protein like 1 is known to operate within the chromatin environment, altering this structure can inhibit its activity. MS-275 (Entinostat) functions similarly, but with a selectivity for Class I HDACs, which could lead to a slightly different alteration in chromatin regions and thus influence the Sp140 nuclear body protein like 1 activity. RGFP966, by targeting specifically HDAC3, and Mocetinostat, which inhibits Class I and IV HDAC enzymes, contribute to the increase of acetylation levels that might disrupt the functional activity of Sp140 nuclear body protein like 1 by changing gene expression patterns.
On the other hand, Sirtinol and Splitomicin inhibit sirtuin deacetylases such as SIRT1 and SIRT2. These enzymes, like HDACs, remove acetyl groups, but they are NAD+-dependent, indicating a different regulatory mechanism that can also affect the function of Sp140 nuclear body protein like 1. Nicotinamide, a SIRT inhibitor, can disrupt Sp140 nuclear body protein like 1 activity by preventing sirtuin-mediated deacetylation. Panobinostat acts as a broad-spectrum HDAC inhibitor, altering the acetylation of both histones and non-histone proteins, which can influence Sp140 nuclear body protein like 1 by modifying the chromatin landscape extensively. Similarly, Chidamide selectively inhibits HDAC to affect the acetylation status of proteins and histones, thereby influencing the activity of Sp140 nuclear body protein like 1. Scriptaid, another HDAC inhibitor, operates within this same paradigm, targeting the acetylation status of histones to exert its influence on Sp140 nuclear body protein like 1. Lastly, CUDC-101's inhibition of multiple pathways, including HDAC, EGFR, and HER2, can result in altered signaling environments and chromatin modifications, which can collectively inhibit the activity of Sp140 nuclear body protein like 1.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs). By doing so, it can alter chromatin structure and affect DNA accessibility, potentially leading to the suppression of Sp140 nuclear body protein like 1 activity due to changes in the chromatin environment where the protein operates. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA, another HDAC inhibitor, can also alter chromatin dynamics, leading to the inhibition of Sp140 nuclear body protein like 1, as it may depend on specific acetylation patterns for its function. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 selectively inhibits Class I HDACs, which can result in an inhibition of Sp140 nuclear body protein like 1 by modifying the chromatin regions where the protein acts and potentially disrupting its interaction with the chromatin. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
RGFP966 is an HDAC3-specific inhibitor, which by inhibiting HDAC3, can lead to an increase in acetylation levels that might disrupt the functional activity of Sp140 nuclear body protein like 1 through changes in gene expression patterns. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $37.00 $111.00 | 14 | |
Sirtinol acts as an inhibitor of sirtuin deacetylases, particularly SIRT1 and SIRT2, which can result in the inhibition of Sp140 nuclear body protein like 1 activity by affecting deacetylation processes that are critical for its normal function. | ||||||
Splitomicin | 5690-03-9 | sc-358701 | 5 mg | $47.00 | ||
Splitomicin is a selective inhibitor of the NAD+-dependent deacetylase SIRT1, which through its inhibition, can lead to changes in protein complexes that include Sp140 nuclear body protein like 1, thereby inhibiting its function. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is a SIRT inhibitor that can disrupt the activity of Sp140 nuclear body protein like 1 through inhibition of sirtuin-mediated deacetylation, potentially altering the protein's interaction with other nuclear components. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is an HDAC inhibitor known to inhibit Class I & IV HDAC enzymes, leading to chromatin remodeling that can inhibit the functional activity of Sp140 nuclear body protein like 1 by affecting the structural context of its action sites. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent pan-HDAC inhibitor and can inhibit Sp140 nuclear body protein like 1 function by broadly altering histone and protein acetylation, affecting chromatin structure and gene expression in the domains where the protein is active. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $61.00 $245.00 $1173.00 | ||
Chidamide is a selective HDAC inhibitor that can inhibit Sp140 nuclear body protein like 1 by affecting the acetylation status of histones and non-histone proteins, potentially disrupting the protein's regulatory functions in chromatin. | ||||||