Panobinostat CAS: 404950-80-7
MF: C21H23N3O2
MW: 349.43

Panobinostat (CAS 404950-80-7)

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备用名: Panobinostat is also known as LBH-589.
应用; Panobinostat is a histone deacetylase (HDAC) inhibitor reported to inhibit human multiple myeloma cell lines.
CAS号码: 404950-80-7
纯度: ≥98%
分子量: 349.43
分子式: C21H23N3O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. Panobinostat has potential applications in several different forms of cancer, in addition to spinal muscular atrophy and HIV therapy.


参考文献

1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695

2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412

3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321

4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).
保存 :
Store at -20° C
熔点 :
>115° C (dec.)
沸点 :
608.15° C (Predicted)
折射率 :
n20D 1.68 (Predicted)
IC50 :
Histone deacetylase: IC50 = 1.8 nM (Plasmodium falciparum); HDAC1: IC50 = 6.8 nM (human); COLO 205: IC50 = 18 nM (human); PC-3: IC50 = 24 nM (human); A2780: IC50 = 35 nM (human)
Ki 数据 :
HDAC4: Ki= 0.6 nM (human); HDAC2: Ki= 0.65 nM (human); HDAC6: Ki= 0.7 nM (human); HDAC5: Ki= 0.7 nM (human); HDAC1: Ki= 1 nM (human)
pK值 :
pKa: 8.71 (Predicted), pKb: 9.3 (Predicted)
仅供科研使用。不可用于诊断或治疗。
RTECS :
UC6378000
PubChem CID :
MDL 号码 :
MFCD09833242
SMILES :
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

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PMID: # 30515817  Liao, W. et al. 2019. J. Cell. Physiol. 234: 12646-12662.

PMID: # 31054975  Ali, I.|Ruiz, DG.|Ni, Z.|Johnson, JR.|Zhang, H.|Li, PC.|Khalid, MM.|Conrad, RJ.|Guo, X.|Min, J.|Greenblatt, J.|Jacobson, M.|Krogan, NJ.|Ott, M.| et al. 2019. Mol. Cell. 74: 1164-1174.e4.

PMID: # 29778644  Hepp, MI. et al. 2018. Biochim. Biophys. Acta.

PMID: # 26379230  Franken, H. et al. 2015. Nat Protoc. 10: 1567-93.

PMID: # 32365976  Cancers (Basel). 12:

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