RGFP966 的分子结构, CAS编号: 1357389-11-7
RGFP966 (CAS 1357389-11-7)
备用名:
(2E)-N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
CAS号码:
1357389-11-7
分子量:
362.4
分子式:
C21H19FN4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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描述
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RGFP966 (CAS 1357389-11-7) 参考文献
- RGFP966 通过抑制表皮生长因子受体在体外肝癌细胞中的表达抑制肿瘤生长和迁移。 | Yu, X., et al. 2020. Drug Des Devel Ther. 14: 121-128. PMID: 32021097
- 组蛋白去乙酰化酶3抑制剂RGFP966通过SMAD7阻断TGF-β信号传导，促进胶质瘤干细胞分化。 | Liang, H., et al. 2020. Biochem Pharmacol. 180: 114118. PMID: 32585142
- 组蛋白去乙酰化酶 3 选择性抑制剂 RGFP966 通过保护 β 细胞改善糖耐量受损。 | Lei, L., et al. 2020. Toxicol Appl Pharmacol. 406: 115189. PMID: 32800772
- RGFP966 使 YAP 通路失活可减轻长时间低体温保存引起的心脏功能障碍。 | Zheng, XH., et al. J Zhejiang Univ Sci B. 21: 703-715. PMID: 32893527
- 选择性 HDAC3 抑制剂 RGFP966 可改善 OVA 诱导的过敏性鼻炎小鼠模型的过敏和炎症反应。 | Zhang, W., et al. 2021. Int Immunopharmacol. 93: 107400. PMID: 33529911
- HDAC3 抑制剂 RGFP966 在结核分枝杆菌感染过程中控制细菌生长并调节巨噬细胞信号传导。 | Campo, M., et al. 2021. Tuberculosis (Edinb). 127: 102062. PMID: 33639591
- RGFP966 通过抑制神经炎症和小胶质细胞活化，对脂多糖诱发的小鼠抑郁样行为具有保护作用。 | Bian, HT., et al. 2021. Int Immunopharmacol. 101: 108259. PMID: 34666303
- RGFP966通过HDAC3/Nrf2途径发挥大鼠手术脑损伤后的神经保护作用 | Gu, HP., et al. 2023. Heliyon. 9: e18160. PMID: 37539293
- HDAC3 畸变导致的 GPX4 抑制推动了肾脏铁变态反应和 AKI-CKD 进展。 | Zhang, L., et al. 2023. Redox Biol. 68: 102939. PMID: 37890360
- 鉴定星形胶质细胞反应性化学调节剂的表型筛选平台。 | Clayton, BLL., et al. 2024. Nat Neurosci. 27: 656-665. PMID: 38378993
抑制剂：
4632411B12Rik, A-Myb, A530032D15Rik, AIP4, Bdf1, BEND7, CAF-1 p150, CHD9, CREST, DPF3, ELP4, Gal11, Hat2, HDAC10, HDAC3, HDAC4, HDAC5, HiNF-P, His-probe, Histone cluster 1 H2AA, Histone cluster 1 H2AB, Histone cluster 1 H2AC, Histone cluster 1 H2AD, Histone cluster 1 H2AE, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AL, Histone cluster 1 H2AM, Histone cluster 1 H2BA, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H3H, Histone cluster 2 H3C, Histone cluster 2 H3D, Histone cluster 2 H4B, Histone H2A, HLF, HUD, INTS10, INTS8, INTS9, mage-k1, MASGP-BP, MIER3, Morc, MORF, Msx-3, NOPAR, NTS12, OTTMUSG00000016779, Plectin, PRDM16, PSF, R3HDML, SAMD4B, SAP 25_Sap25, Sin4p, SMARCD2, Snf5, Sox-9, ST7, Sum1, TAF I p63_TAF I p68, TAF6L, THAP7, TMEM59, UBN-1, VPS72, WDR33, ZBP-89, Zfp13, ZFP563, ZKSCAN1, ZMYND12, ZMYND17, ZNF131, ZNF430, ZNF585A, ZNF588, ZNF606, ZNF764, ZNF806, 和 ZSCAN1.激活剂：
4930557A04Rik, ASCL2, Ataxin-1, CARM1, CHD2, CTDSPL2, DPPA4, EFO2, EG385328, EG434729, EG546205, EID-1, H2AL2, H2al2y, H2BFA, Histone cluster 1 H2AH, Histone cluster 1 H3J, Histone cluster 2 H2AB, Histone cluster 2 H2AC, Histone H2B, INO80B, Josephin-3, L3MBTL3, LANPL, MEAF6, Med10, Med11, Med19, MORF4L1, MRG15, NAP1L3, NSBP1, PABPC4, periphilin 1, RNF20, SA-2, SAP 18, SmcX, Spt7, SSU72, STH1, SYT, TADA3L, TAF II p43, TCF-19, TRAP100, YAF2, 和 ZSCAN18.订购信息
| 产品名称 | 产品编号 | 规格 | 价格 | 数量 | 收藏夹 | |
RGFP966, 5 mg | sc-507300 | 5 mg | $115.00 |