8-oxoG DNA Lesion Inhibitors

Chemical Class Description: The class of 8-oxoG DNA lesion inhibitors consists of compounds that indirectly modulate the formation and repair of 8-oxoG lesions by targeting oxidative stress and DNA repair mechanisms. These compounds, while not interacting directly with 8-oxoG, influence the cellular antioxidant capacity and DNA repair pathways. Antioxidants like N-Acetylcysteine, Vitamin C, Vitamin E, Curcumin, Resveratrol, Quercetin, Lycopene, Silymarin, Green Tea Extract, and Melatonin can reduce the levels of oxidative stress in cells, limiting the formation of oxidative DNA lesions like 8-oxoG.

Minerals like Zinc and Selenium, essential for numerous biological processes, play crucial roles in enhancing the body's antioxidant defenses and facilitating DNA repair mechanisms. Zinc is known for its role in various enzymatic reactions, including those in DNA repair pathways, while Selenium is a component of antioxidant enzymes like glutathione peroxidase. The use of these compounds can be a strategic approach to reducing oxidative stress and enhancing DNA repair, thereby indirectly limiting the formation and persistence of 8-oxoG lesions, a common form of oxidative DNA damage.