6CKine Activators
Chemical agents classified as 6CKine Activators influence the activation or expression of the 6CKine protein, also known as CCL21. This protein plays a pivotal role in directing the migration of T cells and dendritic cells to secondary lymphoid organs. While no direct chemical activators for 6CKine have been identified, various agents can indirectly influence its activity by affecting related cellular processes and signaling pathways. For example, Tumor Necrosis Factor-alpha (TNF-α) and Interferon-gamma (IFN-γ) can enhance the expression of CCL21 by acting on endothelial cells in lymphoid organs and various cell types, respectively. Lipopolysaccharide, on the other hand, stimulates the release of CCL21 by acting on macrophages and dendritic cells.
Phorbol Myristate Acetate and Forskolin influence specific signaling pathways, such as protein kinase C and cAMP, respectively, which can alter the expression of CCL21. Additionally, chemicals like Dexamethasone, Epidermal Growth Factor, and Retinoic Acid can modulate gene expression or specific pathways, providing indirect mechanisms by which they influence CCL21 expression. The ability of these chemicals to affect the 6CKine protein underscores the intricate network of signaling pathways and cellular processes that regulate its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Can stimulate the release of CCL21 by acting on macrophages and dendritic cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Acts on protein kinase C pathway and can potentially influence the expression of CCL21 in dendritic cells. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Acts through the cAMP pathway, potentially increasing the expression of CCL21 in certain cell types. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid receptor agonist that can influence various pathways, possibly including those that regulate CCL21. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Through the vitamin D receptor, can influence numerous genes, possibly including those that regulate CCL21. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Influences NF-κB and other pathways, which can indirectly influence CCL21 expression. | ||||||