6720456B07Rik Inhibitors
Chemical class Brk1 Inhibitors includes compounds that can indirectly alter the functional activity of BRK1 through modulation of the actin cytoskeleton and its associated signaling pathways. These chemicals are not specific antagonists of BRK1 but affect the cellular processes that BRK1 is known to influence. The compounds range from those that bind to actin monomers, like Latrunculin A, to those that inhibit proteins involved in actin filament formation and stabilization, like Jasplakinolide and Phalloidin. By altering the dynamics of actin polymerization and depolymerization, these chemicals can change the way BRK1 and its associated WAVE complex facilitate actin nucleation and branching.
Furthermore, chemicals like Y-27632 and Blebbistatin target kinases and motor proteins that are crucial for actin-myosin contractility, a process essential for the proper functioning of the actin cytoskeleton. By inhibiting these proteins, the chemicals can disrupt the downstream effects that BRK1 has on cell morphology and motility. In addition, inhibitors like Chelerythrine, which target protein kinase C, can modulate signaling pathways that influence actin remodeling and, by extension, the activities of BRK1.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Can bind to actin monomers and prevent their polymerization, thereby potentially affecting the actin-nucleating activity regulated by the BRK1-containing WAVE complex. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Can block actin filament elongation by capping the fast-growing end of the filament, potentially altering the dynamics of actin structures governed by the BRK1 complex. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Can stabilize actin filaments and prevent their disassembly, which can alter the balance of actin dynamics that the BRK1 complex is involved in regulating. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Can sever actin filaments and reduce the amount of filamentous actin, potentially disrupting the actin-related functions of the BRK1 complex. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Can inhibit myosin II activity and thus can affect actin-myosin interactions, possibly influencing the cellular processes where BRK1 plays a role. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Can inhibit ROCK (Rho-associated protein kinase), which is involved in actin cytoskeleton organization, potentially modulating the activity of the BRK1 complex. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Can inhibit Arp2/3 complex-mediated actin nucleation, potentially altering the actin cytoskeleton remodeling where BRK1 is implicated. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Can inhibit myosin light chain kinase (MLCK), potentially affecting actin and myosin interaction and thereby influencing the BRK1 complex's role in actin dynamics. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Can inhibit the N-WASP which is part of the actin nucleation core complex, potentially affecting the regulation of actin polymerization by the BRK1 complex. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Can inhibit formin-mediated actin nucleation and elongation, which can impact the actin architecture that the BRK1 complex is associated with. | ||||||