5033414D02Rik Inhibitors
Chemical inhibitors of the protein 5033414D02Rik are diverse in their mechanisms of action, each targeting specific signaling pathways that can lead to the functional inhibition of this protein. Wortmannin and LY294002, both phosphoinositide 3-kinases (PI3K) inhibitors, block the PI3K/AKT signaling pathway which is fundamental for various cellular functions. The inhibition of PI3K leads to reduced activation of AKT, subsequently disrupting downstream signaling that may involve 5033414D02Rik. This disruption can prevent 5033414D02Rik from participating in its normal cellular roles. Similarly, rapamycin, an mTOR inhibitor, blocks the mTOR pathway, which is crucial for cell growth and proliferation. By inhibiting mTOR, rapamycin prevents the activation of proteins downstream of mTOR, which can include 5033414D02Rik, thereby inhibiting its function.
Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit the activity of a wide array of kinases, which can affect phosphorylation-dependent signaling processes essential for the function of many proteins, including 5033414D02Rik. SB203580 and SP600125 selectively inhibit p38 MAPK and JNK, respectively, which are kinases involved in stress and inflammatory responses. The inhibition of these kinases can hinder the signaling cascades in which 5033414D02Rik may play a part. PD98059 and U0126 target MEK1/2, key components of the MAPK/ERK pathway, and their inhibition can result in reduced ERK activation, affecting proteins associated with this pathway, such as 5033414D02Rik. Furthermore, Y-27632, an inhibitor of ROCK, can lead to alterations in cell motility and proliferation by preventing the signaling that 5033414D02Rik might influence. Lastly, ZM-447439, which targets Aurora kinases implicated in cell division, can disrupt processes that are vital for the proper functioning of 5033414D02Rik during cell cycle progression. Each chemical, through its distinct inhibitory action, can contribute to the modulation of 5033414D02Rik's activity within various cellular contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that prevents mTOR from activating downstream proteins required for cell cycle progression. By inhibiting this pathway, rapamycin can halt cellular processes that rely on mTOR signaling. As 5033414D02Rik may play a role in signaling pathways that are regulated by mTOR, the use of rapamycin can result in functional inhibition of 5033414D02Rik by preventing its downstream signaling events. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a non-selective inhibitor of protein kinases. Its ability to inhibit a broad range of kinases can lead to the inhibition of phosphorylation events critical for various signaling pathways. Inhibition of these kinases can functionally inhibit downstream proteins such as 5033414D02Rik by preventing necessary phosphorylation events for its activation or function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. Inhibition of p38 MAPK can lead to the suppression of downstream signaling pathways that are crucial for cellular stress responses, cytokine production, and apoptosis. As 5033414D02Rik is involved in cellular signaling, the inhibition of p38 MAPK can disrupt pathways necessary for the functional activity of 5033414D02Rik. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. By inhibiting MEK, PD98059 prevents the activation of ERK and its subsequent signaling. Since the MAPK pathway is implicated in a variety of cellular functions, the inhibition of MEK and thus ERK can hinder the signaling processes in which 5033414D02Rik is involved, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a chemical inhibitor of PI3K. Similar to Wortmannin, it impedes the PI3K pathway, leading to reduced AKT phosphorylation and activity. As a consequence, downstream signaling pathways involving 5033414D02Rik can be functionally inhibited due to the lack of PI3K signaling, which is necessary for the proper function of numerous proteins within the cell. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, which are upstream regulators of the ERK pathway. Through the inhibition of MEK, U0126 can suppress ERK activation, which in turn can lead to the functional inhibition of proteins involved in the MAPK/ERK pathway, including 5033414D02Rik, by preventing their necessary signaling events. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK is involved in regulating processes like apoptosis, cell differentiation, and immune responses. Inhibition of JNK by SP600125 can lead to the functional inhibition of downstream proteins that are part of the JNK signaling pathway, including 5033414D02Rik, by hindering the pathway's signaling capabilities. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK). ROCK is implicated in various cellular functions including contraction, motility, proliferation, and apoptosis. Inhibition of ROCK by Y-27632 can lead to the functional inhibition of downstream signaling pathways that involve 5033414D02Rik, by preventing the necessary signaling events that ROCK regulates. | ||||||