4931429I11Rik Inhibitors
Chemicals classified as Jhy Inhibitors would be those that can influence the activity or function of the junctional cadherin complex regulator, either directly or indirectly by affecting the signaling pathways and cellular processes related to cadherin-mediated cell adhesion. These compounds have diverse mechanisms of action, ranging from calcium chelation, which is critical for cadherin function, to the inhibition of signaling pathways such as PI3K, Wnt/β-catenin, Notch, TGF-β, MAPK/ERK, and others, all of which can modulate the expression, localization, and function of cadherin complexes and, consequently, Jhy.
The interaction between cadherins and the actin cytoskeleton is also crucial for the maintenance of cell junctions. Compounds such as blebbistatin, ML-7, and Y-27632 act on the cytoskeleton and cell contractility, thereby potentially influencing the function of Jhy within the cadherin complexes. Through their varied effects on intracellular signaling and cytoskeletal dynamics, these compounds represent a range of possible indirect modulators of Jhy activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
A calcium chelator that can disrupt calcium-dependent cadherin-cadherin interactions, potentially affecting Jhy-related cadherin complexes. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
Calmodulin antagonist that can affect calcium signaling, thereby potentially influencing Jhy-associated cadherin function. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Protein kinase C inhibitor that can modulate signaling pathways involved in cadherin-mediated adhesion, possibly impacting Jhy function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that can alter intracellular signaling pathways, potentially affecting Jhy by modifying cadherin-cadherin interactions. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Inhibits Wnt/β-catenin signaling, a pathway that can regulate cadherin expression and function, possibly influencing Jhy activity. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
Gamma-secretase inhibitor that can affect Notch signaling, a pathway that can modulate cadherin-mediated cell adhesion, potentially affecting Jhy. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor that may influence cadherin function and epithelial-mesenchymal transition, potentially impacting Jhy. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
MEK inhibitor that can affect the MAPK/ERK pathway, potentially influencing Jhy through altered cadherin signaling. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Inhibits myosin II activity and can affect cell contractility and adhesion, potentially impacting Jhy's role in cadherin complex regulation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Myosin light chain kinase inhibitor that can affect cytoskeletal dynamics and cell adhesion, potentially impacting Jhy activity. | ||||||