4931429I11Rik Inhibitors

Chemicals classified as Jhy Inhibitors would be those that can influence the activity or function of the junctional cadherin complex regulator, either directly or indirectly by affecting the signaling pathways and cellular processes related to cadherin-mediated cell adhesion. These compounds have diverse mechanisms of action, ranging from calcium chelation, which is critical for cadherin function, to the inhibition of signaling pathways such as PI3K, Wnt/β-catenin, Notch, TGF-β, MAPK/ERK, and others, all of which can modulate the expression, localization, and function of cadherin complexes and, consequently, Jhy.

The interaction between cadherins and the actin cytoskeleton is also crucial for the maintenance of cell junctions. Compounds such as blebbistatin, ML-7, and Y-27632 act on the cytoskeleton and cell contractility, thereby potentially influencing the function of Jhy within the cadherin complexes. Through their varied effects on intracellular signaling and cytoskeletal dynamics, these compounds represent a range of possible indirect modulators of Jhy activity.