4931407G18Rik Inhibitors

The chemical class referred to as Cabs1 Inhibitors includes a variety of compounds that can indirectly modulate the function of the Cabs1 protein through their effects on cellular calcium dynamics. Since Cabs1 is a calcium-binding protein, any alteration in intracellular calcium levels or calcium signaling can impact its activity. Compounds such as Verapamil, Nifedipine, Amlodipine, and Bepridil are recognized as calcium channel blockers, which can diminish the influx of calcium ions from the extracellular space into the cytoplasm, thereby potentially affecting the calcium-dependent activities of Cabs1.

On the other hand, agents like Dantrolene, Thapsigargin, and Ryanodine target specific components of the sarcoplasmic/endoplasmic reticulum, such as the ryanodine receptors and SERCA pumps, which are responsible for the storage and release of calcium within cells. By modulating these intracellular calcium stores, these compounds can influence the concentration of calcium ions available for binding to Cabs1. Additionally, 2-APB and TMB-8 are known to affect intracellular calcium signaling by inhibiting IP3 receptors and internal calcium release, which can also impact Cabs1.