4930525F21Rik Inhibitors

The chemical class described as Fam227b Inhibitors encompasses a range of compounds that act on various signaling pathways potentially associated with the biological activities of Fam227b. These inhibitors target different kinases and enzymes involved in cellular processes such as cell growth, proliferation, and protein phosphorylation, which may be connected to the functional network of Fam227b. The inhibitors include Wortmannin and LY294002, which target PI3K, thereby potentially affecting any PI3K-mediated effects related to Fam227b. PD98059 and U0126 are both MEK inhibitors, impacting the MAPK/ERK pathway, and could therefore modulate the activity of Fam227b if it interacts with this pathway.

Further, SB203580 and SP600125 inhibit p38 MAPK and JNK, respectively, pathways that could be relevant to Fam227b's role in cellular signaling. Rapamycin and Triciribine disrupt mTOR and AKT signaling, which are crucial for cell cycle and survival signals, possibly influencing Fam227b. Bortezomib, a proteasome inhibitor, could affect the degradation of proteins associated with Fam227b, altering its functional interactions within the cell. Dasatinib and PP2, as Src family kinase inhibitors, might change the phosphorylation patterns of proteins in pathways involving Fam227b.