2810403A07Rik Inhibitors
The chemical class known as Khdc4 Inhibitors encompasses compounds that can indirectly affect the function of Khdc4 by targeting various aspects of the pre-mRNA splicing process. These compounds range from specific inhibitors of the spliceosomal machinery to broader acting molecules that can alter cellular functions related to splicing.
Pladienolide B and its derivatives, including Meayamycin B and E7107, bind to components of the spliceosome, thereby directly inhibiting its function and potentially affecting the splicing factor activity of Khdc4. Compounds like Sudemycin D6 and Madrasin also modify spliceosome activity, which can alter the processing of pre-mRNA transcripts where Khdc4 would normally play a role. Spliceostatin A and Herboxidiene share a similar mechanism, targeting the SF3b complex of the spliceosome, which is essential for spliceosome catalytic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Targets the spliceosome, potentially disrupting the splicing of pre-mRNAs where Khdc4 is involved. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
A biflavonoid compound that inhibits the spliceosome assembly, influencing pre-mRNA splicing. | ||||||
Madrasin | 374913-63-0 | sc-507563 | 100 mg | $750.00 | ||
Inhibits splicing by affecting the spliceosomal assembly, potentially impacting Khdc4's role in splicing. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Binds to the SF3b complex and inhibits spliceosome-mediated splicing, which can affect Khdc4 activity. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Another SF3b binding compound that alters spliceosome function which may disrupt Khdc4's role. | ||||||
FR901464 | 146478-72-0 | sc-507352 | 5 mg | $1800.00 | ||
Originally discovered as a natural product that targets the spliceosome and affects splicing factors. | ||||||
Chlorhexidine | 55-56-1 | sc-252568 | 5 g | $101.00 | 3 | |
Known for its antiseptic properties, can nonspecifically interact with nucleic acids and potentially affect RNA processing. | ||||||
Quinomycin A | 512-64-1 | sc-202306 | 1 mg | $163.00 | 4 | |
A quinoxaline antibiotic that intercalates into DNA and, although not specific, may perturb RNA processing mechanisms. | ||||||
Thiostrepton | 1393-48-2 | sc-203412 sc-203412A | 1 g 5 g | $115.00 $415.00 | 10 | |
A thiopeptide antibiotic that can inhibit FOXM1, a transcription factor involved in cell cycle regulation and potentially pre-mRNA splicing regulation. | ||||||