X11γ Antibody (A-2): sc-271422

X11γ Antibody (A-2) is a mouse monoclonal IgG1 antibody that detects X11γ in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11γ, a member of the X11 family of proteins, plays a crucial role in the regulation of β-Amyloid precursor protein (β-APP) processing, which is significant in the context of Alzheimer′s disease. X11γ is primarily located in the cytoplasm and at the synapses of neurons, where X11γ interacts with β-APP via its phosphotyrosine binding (PTB) domain. X11γ binding to β-APP not only reduces the secretion of cellular β-APP but also modulates β-APP internalization, thereby influencing the pathways that lead to amyloid plaque formation. X11γ′s location in the cell is crucial for synaptic function and neuronal signaling, which are critical for maintaining cognitive health. Additionally, multiple splice variants of X11, including X11α and X11β, highlight the complexity of regulatory mechanisms and potential implications in neurodegenerative diseases. anti-X11γ antibody (A-2) is an essential tool for researchers investigating the molecular pathways associated with Alzheimer′s disease and the role of β-APP in neuronal health.

The preferred X11γ antibody is X11γ Antibody (B-6): sc-390819.