X11γ Antibody (32): sc-136121
- X11γ Antibody (32) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 63-185 of X11γ of mouse origin
- recommended for detection of X11γ of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for X11γ Antibody (32). This work is in progress.
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X11γ Antibody (32) is a mouse monoclonal IgG1 antibody that detects X11γ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). X11γ is a neuronal, transmembrane protein that plays a crucial role in modulating the processing of the β-Amyloid precursor protein (β-APP), which is a significant factor in the development of Alzheimer′s disease. By binding to the YENPTY motif of β-APP via its phosphotyrosine binding (PTB) domain, X11γ reduces the secretion of cellular β-APP and slows down its processing pathways, thereby influencing amyloid plaque formation. The interaction between X11γ and β-APP is vital for maintaining cellular homeostasis and preventing neurodegeneration, making X11γ an important target for research into therapeutic strategies for Alzheimer′s disease. Additionally, multiple splice variants of X11 have been identified, including X11α (Mint 1), X11β (Mint 2), and X11γ (Mint 3), each contributing to the complex regulation of β-APP and its associated pathways. Anti-X11γ antibody (32) is an essential tool for researchers investigating the molecular mechanisms underlying Alzheimer′s disease and the role of β-APP processing in neurodegeneration.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
X11γ Antibody (32) | sc-136121 | 50 µg/0.5 ml | $322.00 |