TTP Antibody (H-8): sc-376162
- TTP Antibody (H-8) is a mouse monoclonal IgG1 λ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-29 at the N-terminus of TTP of human origin
- recommended for detection of TTP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See TTP (A-8): sc-374305 for TTP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for TTP Antibody (H-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with TTP Antibody (H-8) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
TTP Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects tristetraprolin (TTP) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TTP is a crucial zinc-binding protein encoded by the immediate-early response gene Zfp-36, playing a significant role in the regulation of mRNA stability and inflammatory responses. TTP (H-8) antibody recognizes TTP′s ability to bind to AU-rich elements in the 3′ untranslated region of target mRNAs, leading to their degradation and thus negatively regulating the expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α). This regulatory mechanism is vital for maintaining immune homeostasis, as evidenced by studies showing that knockout mice deficient in TTP develop severe autoimmune conditions, including inflammatory arthritis and dermatitis. The phosphorylation of TTP by p42 MAP kinase upon mitogen stimulation further highlights its dynamic role in cellular signaling, as this modification facilitates TTP translocation from the nucleus to the cytoplasm, thereby modulating activity and function in response to extracellular signals. Anti-TTP antibody (H-8) serves as an essential tool for researchers investigating the molecular mechanisms underlying immune regulation and inflammatory diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TTP Antibody (H-8) | sc-376162 | 200 µg/ml | $322.00 | |||
TTP Antibody (H-8): m-IgGλ BP-HRP Bundle | sc-522857 | 200 µg Ab, 40 µg BP | $361.00 | |||
TTP (H-8) Neutralizing Peptide | sc-376162 P | 100 µg/0.5 ml | $69.00 |