TRK-T3 Antibody (E-7): sc-515055

TRK-T3 Antibody (E-7) is a mouse monoclonal IgG2b antibody that detects TRK-T3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRK-T3 is a fusion protein resulting from oncogenic rearrangements of the NTRK1 gene, which encodes the Trk A protein, and is particularly significant in thyroid carcinomas where these rearrangements are frequently observed. TRK-T3 protein is characterized by a coiled-coil motif within the TFG region, which is crucial for forming protein complexes, thereby facilitating various signaling pathways. This structural feature allows TRK-T3 to interact with key adaptor proteins such as Shc and SNT1/FRS2, which play essential roles in linking receptor tyrosine kinases to the mitogen-activated protein kinase pathway, ultimately influencing cellular proliferation and survival. Additionally, TRK-T3 interaction with SHP-1, a phosphatase that down-regulates activity, highlights the importance of post-translational modifications in regulating signaling dynamics of this oncoprotein. Anti-TRK-T3 antibody (E-7) is an invaluable tool for researchers investigating molecular mechanisms underlying NTRK1-related oncogenesis and functional implications of TRK-T3 in various biological contexts.

The preferred TRK-T3 antibody is TRK-T3 Antibody (H-11): sc-515054.