TIMP-1 Antibody (G-6): sc-365905

TIMP-1 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TIMP-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIMP-1 Antibody (G-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TIMP-1 plays a crucial role in regulating extracellular matrix remodeling by inhibiting metalloproteinases, which are enzymes responsible for degrading various components of the extracellular matrix. This function is particularly important in processes such as wound healing, tissue repair, and cancer progression, where maintaining balance between matrix degradation and synthesis is vital for tissue integrity. TIMP-1 interacts with other tissue inhibitors of metalloproteinases, including TIMP-2, TIMP-3, and TIMP-4, which further underscores TIMP-1′s significance in modulating metalloproteinase activity and influencing cellular behaviors. TIMP-1 expression is regulated by various factors, including parathyroid hormone, highlighting TIMP-1′s involvement in complex signaling pathways that govern cellular responses in different physiological and pathological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TIMP-1 Antibody (G-6) References:

1. Involvement of TIMP-1 in PECAM-1-mediated tumor dissemination.  |  Abraham, V., et al. 2018. Int J Oncol. 53: 488-502. PMID: 29845213
2. TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling.  |  Nicaise, AM., et al. 2019. Mol Neurobiol. 56: 3380-3392. PMID: 30121936
3. TIMP-1-Mediated Chemoresistance via Induction of IL-6 in NSCLC.  |  Xiao, W., et al. 2019. Cancers (Basel). 11: PMID: 31443242
4. A CAF-Fueled TIMP-1/CD63/ITGB1/STAT3 Feedback Loop Promotes Migration and Growth of Breast Cancer Cells.  |  Dittmer, A. and Dittmer, J. 2022. Cancers (Basel). 14: PMID: 36291767
5. Plasma TIMP-1 as a sex-specific biomarker for acute lung injury.  |  Almuntashiri, S., et al. 2022. Biol Sex Differ. 13: 70. PMID: 36482481
6. Circulating tissue inhibitor of metalloproteinases 1 (TIMP-1) at COVID-19 onset predicts severity status.  |  Brusa, S., et al. 2022. Front Med (Lausanne). 9: 1034288. PMID: 36523781
7. TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes.  |  Eckfeld, C., et al. 2023. J Cell Biol. 222: PMID: 36629908
8. The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity.  |  Dimic-Janjic, S., et al. 2023. Eur J Med Res. 28: 127. PMID: 36935521
9. Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses.  |  Sutter, PA., et al. 2024. Proc Natl Acad Sci U S A. 121: e2306816121. PMID: 38266047
10. TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity.  |  Langguth, M., et al. 2024. Genes Immun. 25: 188-200. PMID: 38777826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TIMP-1 Antibody (G-6) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-TIMP-1 Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TIMP-1 Antibody (G-6) Specifications

Alternate Product Name: TIMP1

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 172-207

Epitope Target: TIMP-1

Epitope Species: human

Product Reactivity/Detection: TIMP-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for TIMP-1 Antibody (G-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred TIMP-1 antibody is TIMP-1 Antibody (2A5): sc-21734.