Date published: 2026-10-22
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Tau Antibody (TAU-5) - Western Blotting - Image 401544
Tau 抗体 (TAU-5): sc-58860. 荧光西部印迹分析小鼠脑组织提取物中 Tau 的表达. 使用 UltraCruz® 阻断试剂: sc-516214. 所用检测试剂: m-IgG1 BP-CFL 488: sc-533661.
Tau Antibody (TAU-5) - Western Blotting - Image 401544
Tau 抗体 (TAU-5): sc-58860. 荧光西部印迹分析小鼠脑组织提取物中 Tau 的表达. 使用 UltraCruz® 阻断试剂: sc-516214. 所用检测试剂: m-IgG1 BP-CFL 488: sc-533661.
Tau Antibody (TAU-5) - Western Blotting - Image 17568
Tau 抗体 (TAU-5): sc-58860. 小鼠脑组织提取物中 Tau 表达的 Western 印迹分析.
Tau 抗体 (TAU-5): sc-58860. 荧光西部印迹分析小鼠脑组织提取物中 Tau 的表达. 使用 UltraCruz® 阻断试剂: sc-516214. 所用检测试剂: m-IgG1 BP-CFL 488: sc-533661.

Tau 抗体 (TAU-5): sc-58860

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说明书
  • Tau抗体(TAU-5)是小鼠单克隆IgG1 κ, 在35篇文献中引用，规格为200 µg/ml
  • 针对纯化的Tau bovine 起源
  • 推荐用于 mouse, rat, human 和 bovine 来源的both phosphorylated and non-phosphorylated Tau proteins WB, IP, IF 和 IHC(P)检测; 不会与 tubulin or other microtubule associated proteins产生交联反应
  • 看 Tau (Tau 46): sc-32274，可查看有标记的 Tau 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是Tau Antibody (TAU-5) for WB and IHC(P) applications. 的首选辅助检测试剂，这些试剂现与Tau Antibody (TAU-5) 打包提供（请参阅下面的订购信息）。
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Tau抗体（TAU-5）是一种小鼠单克隆IgG1 kappa轻链抗体，用于识别纯化的牛源性Tau蛋白，特异性靶向人类Tau的C端。Tau单克隆抗体（TAU-5）能够可靠地检测小鼠、大鼠、人类和牛源的磷酸化和非磷酸化Tau蛋白，可用于多种应用，包括蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和石蜡包埋切片免疫组织化学（IHCP）。Tau，也称为MAPT（微管相关蛋白Tau）或TAU，是一种主要由758个氨基酸组成的蛋白质，主要存在于神经细胞质、细胞骨架和细胞膜中。Tau的主要功能是稳定微管，而微管对于维持神经元的结构完整性和促进细胞内运输至关重要。通过促进微管的组装和稳定，Tau在维持神经元的极性和支持细胞骨架可塑性方面发挥着关键作用，而神经元的极性和可塑性对于神经元的正常功能和连接至关重要。Tau（TAU-5）抗体存在多种可变剪接的同工型，在神经元的健康和适应性方面发挥着不同的作用。Tau经历多种翻译后修饰，包括磷酸化、多泛素化和糖化，这些修饰可调节其活性和降解，确保细胞骨架的动态变化。Tau功能和结构的失调与多种神经退行性疾病有关，如阿尔茨海默氏病、苍白球-桥脑-黑质变性（PPND）、皮质基底变性（CBD）和进行性核上性麻痹（PSP），这凸显了维持神经元完整性和在疾病病理学中发挥作用的重要性。Tau（TAU-5）单克隆抗体以非结合形式提供，为研究人员提供了研究Tau在细胞过程和神经退行性疾病中作用的可靠工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Tau 抗体 (TAU-5) 参考文献:

  1. tau的蛋白水解加工。  |  Wang, Y., et al. 2010. Biochem Soc Trans. 38: 955-61. PMID: 20658984
  2. 海马中的Tau磷酸化导致毒性增益功能。  |  Avila, J., et al. 2010. Biochem Soc Trans. 38: 977-80. PMID: 20658988
  3. tau低聚体的病理意义是什么？  |  Cowan, CM., et al. 2012. Biochem Soc Trans. 40: 693-7. PMID: 22817718
  4. 特邀评论：由微管相关蛋白tau基因（MAPT）突变引起的额颞痴呆：神经病理学和神经影像学的变色龙。  |  Ghetti, B., et al. 2015. Neuropathol Appl Neurobiol. 41: 24-46. PMID: 25556536
  5. 对tau蛋白构象的结构评估：方法和途径。  |  Zabik, NL., et al. 2017. Biochem Cell Biol. 95: 338-349. PMID: 28278386
  6. 细胞外Tau蛋白及其在Tau病理传播中的潜在作用。  |  Yamada, K. 2017. Front Neurosci. 11: 667. PMID: 29238289
  7. Tau K280位点的乙酰化调节了tau的磷酸化。  |  Kim, MS., et al. 2023. Int J Neurosci. 133: 1394-1398. PMID: 35603448
  8. 针对Tau的反义寡核苷酸MAPTRx在轻度阿尔茨海默病中的使用：1b期随机安慰剂对照试验。  |  Mummery, CJ., et al. 2023. Nat Med. 29: 1437-1447. PMID: 37095250
  9. Tau、微管动力学和轴突运输：神经退行性疾病的新范式。  |  Cario, A. and Berger, CL. 2023. Bioessays. 45: e2200138. PMID: 37489532
  10. Tau结构域、磷酸化以及与微管的相互作用。  |  Mandelkow, EM., et al. 1995. Neurobiol Aging. 16: 355-62; discussion 362-3. PMID: 7566345

订购信息

产品名称产品编号规格价格数量收藏夹

Tau 抗体 (TAU-5)

sc-58860
200 µg/ml
$322.00

Tau (TAU-5): m-IgG Fc BP-HRP 套装

sc-526916
200 µg Ab; 10 µg BP
$361.00

Tau (TAU-5): m-IgG1 BP-HRP 套装

sc-532289
200 µg Ab; 20 µg BP
$361.00

Is there any data using this antibody as a capture in an ELISA?

Asked by: Paul
Thank you for your question. Tau Antibody is recommended for WB, IP, IF and IHC. We do not recommend the antibody for Sandwich ELISA.
Answered by: BlakeJ
Date published: 2025-09-01

Does this tau5 antibody work for immunoprecipitation in cell or mouse brain lysate?

Asked by: Jiyoen
Thank you for your question. This antibody is fine for immunoprecipitation on mouse brain samples. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Tech Service
Date published: 2017-08-31

Is Tau (TAU-5): sc-58860 available directly conjugated to HRP?

Asked by: jenniferc
Thank you for your question. All requests for directly conjugated versions of this antibody should be directed to our Special Orders team at specialorders@scbt.com Alternatively, consider using Tau (Tau 46): sc-32274, which is available conjugated to agarose, HRP, FITC, PE, and more. (https://www.scbt.com/scbt/product/tau-antibody-tau-46)
Answered by: Technical Support 5
Date published: 2017-01-19
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Rated 4 out of 5 by shreya from works best at 1:50used for western blotting using milk blocking buffer; primary antibody incubation overnight at 4 degree (1:50) 1hr RT secondary incubation at 1:2000 dilution
Date published: 2024-01-02
Rated 5 out of 5 by bod1999 from 效果不错我买了这个产品，效果不错，希望在今后能够继续好用，在今后能够更好的帮助我的实验，为我的论文地基做好贡献。
Date published: 2023-07-23
Rated 5 out of 5 by Keagan from ICCI tested a this for immunocyto staining and it worked very well. I plan to order more for general western blotting as I'm very content with the results
Date published: 2018-08-10
Rated 5 out of 5 by Maisy from Excellent antibodyI received a TAU-5 antibody and performed Western Blotting using brain lysates. I used 1:1000 dilution and got a very good signal.
Date published: 2018-06-19
Rated 5 out of 5 by Sammmy from Strong signal, clean bandsI received a free sample of this antibody and it worked very well even at very low concentrations.
Date published: 2018-01-24
Rated 5 out of 5 by Bill28 from Great WBStrong western blot data; clear signal, low background
Date published: 2017-02-02
Rated 5 out of 5 by jerojero from Excellent!This antibody works great in western blot analysis of Tau expression in mouse brain tissue extract.
Date published: 2017-01-11
Rated 4 out of 5 by TO from Robust band seen in WB using mouse brainRobust band seen in WB using mouse brain tissue extract. -SCBT QC
Date published: 2015-02-03
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Tau 抗体 (TAU-5) is rated 4.7 out of 5 by 9.
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