CD138/SDC1/Syndecan-1 Antibody (SB55a): sc-69833

Syndecan-1 Antibody (SB55a) is a mouse monoclonal IgG2a antibody that detects Syndecan-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Syndecan-1, also known as CD138, is a type I integral membrane proteoglycan that plays a crucial role in cell signaling and adhesion by interacting with components of the extracellular matrix, such as collagens, fibronectin, and thrombospondin. This interaction is vital for maintaining tissue architecture and facilitating cellular communication, particularly in the immune system where Syndecan-1 is expressed on pre-B cells, immature B cells, and plasma cells. Additionally, Syndecan-1 is localized on the basolateral surfaces of epithelial cells and endothelial cells of sprouting capillaries, highlighting Syndecan-1′s importance in vascular development and tissue repair. Syndecan-1′s ability to co-localize with actin-rich filaments suggests a role as a link between the cytoskeleton and the extracellular matrix, thereby influencing cellular morphology and motility. Anti-Syndecan-1 antibody (SB55a) is an essential tool for researchers studying the dynamics of cell adhesion and signaling pathways in various biological contexts.

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CD138/SDC1/Syndecan-1 Antibody (SB55a) References:

1. CD138 (syndecan-1) expression in health and disease.  |  Palaiologou, M., et al. 2014. Histol Histopathol. 29: 177-89. PMID: 24150912
2. Prognostic and clinical significance of syndecan-1 in colorectal cancer: a meta-analysis.  |  Wei, HT., et al. 2015. BMC Gastroenterol. 15: 152. PMID: 26518017
3. Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression.  |  Rangarajan, S., et al. 2020. J Histochem Cytochem. 68: 823-840. PMID: 32623935
4. Glypican 1 and syndecan 1 differently regulate noradrenergic hypertension development: Focus on IP3R and calcium.  |  Potje, SR., et al. 2021. Pharmacol Res. 172: 105813. PMID: 34411733
5. Syndecan-1 Amplifies Ovalbumin-Induced Airway Remodeling by Strengthening TGFβ1/Smad3 Action.  |  Zhang, D., et al. 2021. Front Immunol. 12: 744477. PMID: 34671356
6. The Role and Therapeutic Value of Syndecan-1 in Cancer Metastasis and Drug Resistance.  |  Guo, S., et al. 2021. Front Cell Dev Biol. 9: 784983. PMID: 35118073
7. A Systematic Review of Maternal Serum Syndecan-1 and Preeclampsia.  |  George, K., et al. 2022. Cureus. 14: e25794. PMID: 35836437
8. Maternal plasma syndecan-1: a biomarker for fetal growth restriction.  |  Juusela, A., et al. 2023. J Matern Fetal Neonatal Med. 36: 2150074. PMID: 36597808
9. Syndecan-1 predicts hemodynamic instability in critically ill patients under intermittent hemodialysis.  |  Nascimento de Moura, AC., et al. 2023. Clin Kidney J. 16: 1132-1138. PMID: 37398688
10. Syndecan-1 as a predictor of vulnerable atherosclerotic plaques.  |  Qiu, Y., et al. 2024. Front Cell Dev Biol. 12: 1415788. PMID: 39175877

The preferred CD138/SDC1/Syndecan-1 antibody is CD138/SDC1/Syndecan-1 Antibody (DL-101): sc-12765.