Date published: 2025-9-9

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Synapsin Ia/b 抗体 (B-11): sc-376622

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说明书
  • Synapsin Ia/b抗体(B-11)是小鼠单克隆IgG2a κ, 在5篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Synapsin Ia/b的N-terminus的氨基酸2-29之间
  • 推荐用于 mouse, rat 和 human 来源的a broad range of synapsin family memebers WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 canine, bovine and porcine
  • 2a BP-HRP">m-IgG2a BP-HRP是Synapsin Ia/b Antibody (B-11) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Synapsin Ia/b Antibody (B-11) 打包提供(请参阅下面的订购信息)。

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関連項目

突触素是与突触囊泡相关的磷蛋白,能够调节突触囊泡的外排,并可能参与突触的形成。有证据表明,Synapsin I、Synapsin II和Synapsin IIIa是ATP结合蛋白,其结合受Ca2+和钙调蛋白的调节。已证实Ca2+可以刺激ATP与Synapsin I的结合,对Synapsin II无影响,并抑制Synapsin III的结合。Synapsin I和Synapsin II都经历了选择性剪接,分别产生各自的两种蛋白质形式,即Synapsin Ia和Ib以及Synapsin IIa和IIb。Synapsin III至少产生了三种异构体:Synapsin IIIa、IIIb和IIIc。Synapsin III在早期轴突生长和突触囊泡运输的调节中都发挥着独特的作用。在培养的小鼠海马神经元中,Synapsin III在发育早期即开始表达,在铺板后的第七天其表达水平达到峰值,之后开始下降。Synapsin III高度集中在生长锥中。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Synapsin Ia/b 抗体 (B-11) 参考文献:

  1. 糖皮质激素对应激相关记忆的增强取决于突触蛋白-Ia/Ib。  |  Revest, JM., et al. 2010. Mol Psychiatry. 15: 1125, 1140-51. PMID: 20368707
  2. 单眼剥夺延迟了幼年小鼠对侧视觉皮层中磷酸化的突触蛋白Ia/b在site-1的动态变化。  |  Fu, T., et al. 2015. Neurochem Res. 40: 524-30. PMID: 25576091
  3. 突触蛋白同种型与突触囊泡运输。  |  Song, SH. and Augustine, GJ. 2015. Mol Cells. 38: 936-40. PMID: 26627875
  4. cPKCγ通过调节小鼠神经元中的突触蛋白Ia/b磷酸化来减轻缺血损伤。  |  Zhang, N., et al. 2018. Brain Res Bull. 142: 156-162. PMID: 30016727
  5. 小鼠视觉皮层发育过程中cPKCγ对突触蛋白-Ia/b特异性磷酸化位点的调节。  |  Fu, T., et al. 2019. Invest Ophthalmol Vis Sci. 60: 2676-2684. PMID: 31242289
  6. 磷蛋白突触蛋白Ia调节致密核囊泡释放的动力学。  |  Yang, HJ., et al. 2021. J Neurosci. 41: 2828-2841. PMID: 33632727
  7. 路易体疾病中的α-突触核蛋白生物学。  |  Hoffmann, C., et al. 2021. J Mol Biol. 433: 166961. PMID: 33774037
  8. 突触蛋白诱导的抑制性和兴奋性突触囊泡聚集的不同机制。  |  Song, SH. and Augustine, GJ. 2023. Cell Rep. 42: 113004. PMID: 37597184
  9. 突触蛋白的凝结控制突触囊泡的隔离和动态变化。  |  Hoffmann, C., et al. 2023. Nat Commun. 14: 6730. PMID: 37872159
  10. 突触蛋白2a和突触素3的相互作用调节小鼠的恐惧消退。  |  Shen, XY., et al. 2024. J Clin Invest. 134: PMID: 38175724

订购信息

产品名称产品编号规格价格数量收藏夹

Synapsin Ia/b 抗体 (B-11)

sc-376622
200 µg/ml
$316.00

Synapsin Ia/b (B-11): m-IgG2a BP-HRP 套装

sc-546062
200 µg Ab; 10 µg BP
$354.00

Synapsin Ia/b (B-11) 中和勝肽

sc-376622 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-376622 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Clean detection of Synapsin I a/bThis antibody detects both Synapsin I a/b and Synapsin II in rat neuronal culture lysate at a 1:1000 dilution. Clean background and decent signal for both proteins. Published western blotting data using these antibodies.
Date published: 2018-04-06
Rated 5 out of 5 by from It works well in western blotI bought this antibody four months ago, and used it to detect the synapsin-1 expression in mouse cortex and hippocampus tissue. The conditions were as followed: 1:1000 diluted in 1xPBST buffer, 4℃ for 10 hours. The result was very good, bands were clear, both a and b isoform canbe detected.
Date published: 2017-04-26
Rated 5 out of 5 by from Great Western blot data of Synapsin Ia/bGreat Western blot data of Synapsin Ia/b expression in non-transfected and mouse Synapsin Ia/b transfected 293T whole cell lysates and rat brain tissue extract . -SCBT QC
Date published: 2013-02-24
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Synapsin Ia/b 抗体 (B-11) is rated 5.0 out of 5 by 3.
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