Supervillin Antibody (A-12): sc-393135

Supervillin Antibody (A-12) is a mouse monoclonal IgG1 antibody that detects Supervillin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Supervillin is a crucial member of the Gelsolin superfamily, playing a significant role in actin filament remodeling and various cellular processes, including cell motility, apoptosis regulation, and phagocytosis. Supervillin (A-12) antibody targets a protein predominantly located at the plasma membrane and tightly associated with actin filaments, which is vital for maintaining cellular integrity and facilitating dynamic cellular responses. Supervillin′s presence at the plasma membrane is essential for processes such as cell adhesion and migration, which are critical during development and tissue repair. Additionally, Supervillin exists in different isoforms, with a non-muscle-specific form capable of activating androgen receptor activity, while the muscle-specific isoform, known as Archvillin, is integral to myogenic membrane structures and differentiation. Supervillin′s versatility in various cellular functions underscores its importance in both normal physiology and disease states, making anti-Supervillin antibody (A-12) an invaluable tool for researchers studying these processes.

The preferred Supervillin antibody is Supervillin Antibody (B8C1): sc-53556.