SERCA1 Antibody (VE121G9): sc-58287

SERCA1 Antibody (VE121G9) is a mouse monoclonal IgG1 antibody that detects SERCA1 in mouse, rat, human, rabbit, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SERCA1, a member of the sarcoplasmic or endoplasmic reticulum calcium ATPase family, plays a crucial role in muscle physiology by mediating the uptake of calcium ions into the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. Proper functioning of SERCA1 is vital for maintaining low cytoplasmic calcium concentrations, thereby preventing excessive muscle contraction and ensuring efficient muscle relaxation. This regulation is particularly important in type II (fast) skeletal muscle, where SERCA1 is exclusively expressed, allowing for rapid and powerful muscle contractions. Additionally, SERCA1′s activity is influenced by various post-translational modifications, which can affect function and stability, highlighting the importance of understanding these modifications in the context of muscle health and disease. Anti-SERCA1 antibody (VE121G9) serves as an invaluable tool for researchers studying calcium signaling and muscle physiology, providing insights into the mechanisms underlying muscle function and potential therapeutic targets for muscle-related disorders.

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SERCA1 Antibody (VE121G9) References:

1. Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility.  |  Ennis, IL., et al. 2002. J Clin Invest. 109: 393-400. PMID: 11827999
2. Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles.  |  Kjellgren, D., et al. 2003. Invest Ophthalmol Vis Sci. 44: 5057-62. PMID: 14638697
3. Adenoviral SERCA1 overexpression triggers an apoptotic response in cultured neonatal but not in adult rat cardiomyocytes.  |  Wu, G., et al. 2004. Mol Cell Biochem. 267: 123-32. PMID: 15663193
4. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1.  |  Hino, S., et al. 2007. Hum Mol Genet. 16: 2834-43. PMID: 17728322
5. Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo.  |  O'Donnell, JM., et al. 2008. Am J Physiol Heart Circ Physiol. 295: H2483-94. PMID: 18952713
6. Regulation of fast skeletal muscle activity by SERCA1 vicinal-cysteines.  |  Alvarez, R., et al. 2009. J Muscle Res Cell Motil. 30: 5-16. PMID: 19115048
7. Leishmania spp.-Infected Dogs Have Circulating Anti-Skeletal Muscle Autoantibodies Recognizing SERCA1.  |  Prisco, F., et al. 2021. Pathogens. 10: PMID: 33921323
8. Curcumin Administration Improves Force of mdx Dystrophic Diaphragm by Acting on Fiber-Type Composition, Myosin Nitrotyrosination and SERCA1 Protein Levels.  |  Gorza, L., et al. 2023. Antioxidants (Basel). 12: PMID: 37371910
9. The juxtamembrane sequence of small ankyrin 1 mediates the binding of its cytoplasmic domain to SERCA1 and is required for inhibitory activity.  |  Li, Y., et al. 2025. J Biol Chem. 108216. PMID: 39863105
10. Structure-function relationships in the Ca(2+)-binding and translocation domain of SERCA1: physiological correlates in Brody disease.  |  MacLennan, DH., et al. 1998. Acta Physiol Scand Suppl. 643: 55-67. PMID: 9789547

The preferred SERCA1/2/3 antibody is SERCA1/2/3 Antibody (B-7): sc-271669.