Ribosomal Protein S3 Antibody (E-6): sc-376098
- Ribosomal Protein S3 Antibody (E-6) is a mouse monoclonal IgG2b, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1-243 representing full length Ribosomal Protein S3 of human origin
- recommended for detection of Ribosomal Protein S3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Ribosomal Protein S3 Antibody (E-6) for WB and IHC(P) applications. This reagent is now offered in a bundle with Ribosomal Protein S3 Antibody (E-6) (see ordering information below).
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Ribosomal Protein S3 Antibody (E-6) is a mouse monoclonal IgG2b antibody that detects RPS3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). RPS3 is a crucial component of the 40S ribosomal subunit, playing a significant role in translation and ribosome maturation. RPS3 mediates the formation of the mRNA binding site located 3′ of the codon within the decoding site, which is essential for accurate protein synthesis. Additionally, RPS3 is implicated in DNA damage recognition, demonstrating a strong affinity for abasic sites and 7,8-dihydro-8-oxoguanine residues. This interaction is vital for cellular repair mechanisms, as RPS3 collaborates with human base excision repair proteins such as OGG1 and Ref-1, highlighting RPS3′s importance not only in ribosome function but also in maintaining genomic integrity. With an ability to facilitate both translation and DNA repair, RPS3 serves as a key player in cellular homeostasis, making anti-RPS3 antibody (E-6) an invaluable tool for researchers studying ribosomal function and DNA damage response pathways.
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Ribosomal Protein S3 Antibody (E-6) References:
- Ribosomal protein S3 is secreted as a homodimer in cancer cells. | Kim, Y., et al. 2013. Biochem Biophys Res Commun. 441: 805-8. PMID: 24211576
- Sequential domain assembly of ribosomal protein S3 drives 40S subunit maturation. | Mitterer, V., et al. 2016. Nat Commun. 7: 10336. PMID: 26831757
- Ribosomal protein S3 (rpS3) secreted from various cancer cells is N-linked glycosylated. | Kim, Y., et al. 2016. Oncotarget. 7: 80350-80362. PMID: 27384988
- Ribosomal protein S3 gene silencing protects against experimental allergic asthma. | Dong, J., et al. 2017. Br J Pharmacol. 174: 540-552. PMID: 28093718
- New role of human ribosomal protein S3: Regulation of cell cycle via phosphorylation by cyclin-dependent kinase 2. | Han, SH., et al. 2017. Oncol Lett. 13: 3681-3687. PMID: 28521470
- Chaperone-E3 Ligase Complex HSP70-CHIP Mediates Ubiquitination of Ribosomal Protein S3. | Hwang, I., et al. 2018. Int J Mol Sci. 19: PMID: 30213050
- Knockdown of ribosomal protein S3 causes preimplantation developmental arrest in mice. | Peng, H., et al. 2019. Theriogenology. 129: 77-81. PMID: 30826720
- Ribosomal protein S3 is a novel negative regulator of non-homologous end joining repair of DNA double-strand breaks. | Park, YJ., et al. 2020. FASEB J. 34: 8102-8113. PMID: 32297663
- Ribosomal protein S3 selectively affects colon cancer growth by modulating the levels of p53 and lactate dehydrogenase. | Alam, E., et al. 2020. Mol Biol Rep. 47: 6083-6090. PMID: 32748020
- Ribosomal protein S3-derived repair domain peptides regulate UV-induced matrix metalloproteinase-1. | Yang, HW., et al. 2020. Biochem Biophys Res Commun. 530: 149-154. PMID: 32828277
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ribosomal Protein S3 Antibody (E-6) | sc-376098 | 200 µg/ml | $322.00 | |||
Ribosomal Protein S3 Antibody (E-6): m-IgG2b BP-HRP Bundle | sc-548587 | 200 µg Ab; 10 µg BP | $361.00 |