Quinacrine, Dihydrochloride CAS: 69-05-6
MF: C23H30ClN3O•2HCl
MW: 472.88

Quinacrine, Dihydrochloride (CAS 69-05-6)

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备用名: Atebrine; Mepacrine; Malaricida
应用; Quinacrine, Dihydrochloride is a non-specific PLA2 inhibitor. and acetylcholine receptor antagonist
CAS号码: 69-05-6
纯度: ≥95%
分子量: 472.88
分子式: C23H30ClN3O•2HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Quinacrine dihydrochloride is a non-specific PLA2 (phospholipase A2) inhibitor. Quinacrine, Dihydrochloride acts as an AChR (acetylcholine receptor) antagonist. Quinacrine dihydrochloride suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 μM). This compound also inhibits MAO (monoamine oxidase). Quinacrine, Dihydrochloride is an inhibitor of cPLA2, MAO-A and MAO-B.


参考文献

Holscher, C. 1995. Neurobiol. Learn. Mem. 63, 206. Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117. Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther. 262, 1161. Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev. 21, 33. Murakami, M., et al.

物理状态 :
Solid
溶解度 :
Soluble in water (50 mg/ml with heat, yielding a clear solution), and ethanol (slightly). Insoluble in alcohol, benzene, chloroform, and ether.
保存 :
Store at room temperature
熔点 :
257° C
折射率 :
n20D 1.62 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 0.08 nM; Phospholipase A2: IC50 = 17 µM (porcine pancreas); Human immunodeficiency virus 1: IC50 = 2.15 µM; cPLA2: IC50 = 200 µM (bovine brain); Glibenclamide-sensitive K+-currents: IC50 = 4.4 µM
荧光 :
λex 417 nm, λem 496 nm in 30 mM Tris; 0.2 M sucrose
pK值 :
pKa: pK1: 7.7, pK2: 10.3, pKb: 10.47 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
AR7875000
PubChem CID :
默克索引 :
14: 8044
MDL 号码 :
MFCD00012659
EC号码 :
200-700-8
Beilstein 注册 :
4834013
SMILES :
CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl

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PMID: # 33459338  Foulkes, DM.|McLean, K.|Zheng, Y.|Sarsby, J.|Haneef, A.|Fernig, DG.|Winstanley, C.|Berry, NG.|Kaye, SB.| et al. 2021. Biochem J.

PMID: # 31272829  Fang, MY.|Markmiller, S.|Vu, AQ.|Javaherian, A.|Dowdle, WE.|Jolivet, P.|Bushway, PJ.|Castello, NA.|Baral, A.|Chan, MY.|Linsley, JW.|Linsley, D.|Mercola, M.|Finkbeiner, S.|Lecuyer, E.|Lewcock, JW.|Yeo, GW.| et al. 2019. Neuron.

PMID: # 29879544  Pacheco-Costa, R.|Davis, HM.|Atkinson, EG.|Dilley, JE.|Byiringiro, I.|Aref, MW.|Allen, MR.|Bellido, T.|Plotkin, LI.| et al. 2018. Bone. 114: 22-31.

PMID: # 29899383  Livezey, M. et al. 2018. Cell Death Differ. 25: 1796-1807.

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