PRMT5 Antibody (23C7): sc-136202
- PRMT5 Antibody (23C7) is a mouse monoclonal mouse IgG1, cited in 1 publications, provided at 200 µg/ml
- recommended for detection of PRMT5 of human origin by WB and IP
- See PRMT5 (A-11): sc-376937 for PRMT5 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PRMT5 Antibody (23C7). This work is in progress.
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PRMT5 Antibody (23C7) is a mouse monoclonal IgG1 antibody that detects PRMT5 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. PRMT5 plays a crucial role in the regulation of gene expression and cell proliferation by catalyzing the symmetrical dimethylation of arginine residues on target proteins, a post-translational modification that can significantly influence protein function and interactions. This modification is essential for the assembly of the spliceosome, as it facilitates the proper recruitment and organization of Sm proteins onto small nuclear RNAs (snRNAs). PRMT5 activity is tightly regulated, and dysregulation has been implicated in various cancers, making PRMT5 a potential therapeutic target. Additionally, PRMT5 is predominantly localized in the cytoplasm across a wide range of tissues, where PRMT5 interacts with other proteins involved in transcriptional regulation, including the cyclin E1 promoter, thereby linking PRMT5 to cell cycle control. The gene encoding human PRMT5 is located on chromosome 14q11, highlighting PRMT5′s importance in cellular processes and potential as a biomarker for disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PRMT5 Antibody (23C7) References:
- PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression. | Liu, M., et al. 2020. Theranostics. 10: 4437-4452. PMID: 32292506
- MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage. | Kalev, P., et al. 2021. Cancer Cell. 39: 209-224.e11. PMID: 33450196
- PRMT5 functionally associates with EZH2 to promote colorectal cancer progression through epigenetically repressing CDKN2B expression. | Yang, L., et al. 2021. Theranostics. 11: 3742-3759. PMID: 33664859
- Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response. | Ma, D., et al. 2021. Sci Adv. 7: PMID: 33762328
- Molecular basis for substrate recruitment to the PRMT5 methylosome. | Mulvaney, KM., et al. 2021. Mol Cell. 81: 3481-3495.e7. PMID: 34358446
- Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors in Oncology Clinical Trials: A review. | Feustel, K. and Falchook, GS. 2022. J Immunother Precis Oncol. 5: 58-67. PMID: 36034581
- PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma. | Sloan, SL., et al. 2023. Blood. 142: 887-902. PMID: 37267517
- PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors. | Kim, KH., et al. 2023. Cell Rep. 42: 113329. PMID: 37883229
- MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression. | Sun, Y., et al. 2023. EMBO J. 42: e114558. PMID: 37905571
- Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice. | Katanasaka, Y., et al. 2024. Nat Commun. 15: 2472. PMID: 38503742
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRMT5 Antibody (23C7) | sc-136202 | 200 µg/ml | $322.00 |