Date published: 2025-9-6

021-6093-6350

SCBT Portrait Logo
Seach Input

PP2A-Aα/β 抗体 (4G7): sc-13600

4.7(10)
寫評論提問

说明书
  • PP2A-A alpha / beta 抗体 4G7 是小鼠单克隆 IgG1 κ,PP2A-Aα/β抗体, 在18篇文献中引用,规格为100 µg/ml
  • 与human的PP2A-A的N端区域对应的合成肽的抗原决定簇
  • PP2A-A alpha / beta 抗体 (4G7) 推荐用于 WB, IP, IF 和 IHC(P),检测mouse, rat 和human 来源的 PP2A-Aα and PP2A-Aβ
  • 抗PP2A-A alpha / beta抗体(4G7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取PP2A-Aα/β (4G7): sc-13600免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 PP2A-Aα/β 抗体 (4G7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与PP2A-Aα/β 抗体 (4G7) 组合成套装提供。 (请参阅下面的订购信息)。

快捷链接

関連項目

PP2A-Aα/β抗体(4G7)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和免疫组织化学检测小鼠、大鼠和人类来源的PP2A-Aα/β蛋白。PP2A-Aα/β (4G7) 抗体有非结合型和多种结合型可供选择,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种 Alexa Fluor® 结合物。PP2A-A蛋白作为丝氨酸/苏氨酸磷酸酶在细胞信号传导中发挥着至关重要的作用,对于调节细胞分裂、细胞凋亡和维持细胞内稳态等许多细胞过程至关重要。PP2A-A通过去磷酸化靶蛋白发挥作用,从而逆转激酶的作用,确保细胞内磷酸化平衡。这种调节功能控制着各种信号传导通路,包括与癌症进展和其他疾病相关的信号传导通路。PP2A家族由多个亚基组成,包括PP2A-Aα和PP2A-Aβ,它们可与不同的调节亚基结合形成三聚体全酶,凸显了调节机制的复杂性和多功能性。了解PP2A-A的相互作用和功能对于阐明其在健康和疾病中的作用至关重要,这使得PP2A-Aα/β (4G7)抗体成为研究人员研究这些关键生物学过程的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PP2A-Aα/β 抗体 (4G7) 参考文献:

  1. 小鼠钙调蛋白依赖性蛋白磷酸酶调节亚基(钙调蛋白 B)两种异构体的结构和表达。  |  Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
  2. PP2A 介导的抗癌疗法。  |  Chen, W., et al. 2013. Gastroenterol Res Pract. 2013: 675429. PMID: 24307892
  3. 辛甙元通过激活荚膜细胞中的 PP2A 减轻糖尿病肾病。  |  Zhong, Y., et al. 2019. Nat Commun. 10: 4523. PMID: 31586053
  4. 通过偏向异三聚体稳定选择性增强 PP2A。  |  Leonard, D., et al. 2020. Cell. 181: 688-701.e16. PMID: 32315618
  5. PP2A-Integrator-CDK9 轴对转录进行微调,可作为癌症治疗的靶标。  |  Vervoort, SJ., et al. 2021. Cell. 184: 3143-3162.e32. PMID: 34004147
  6. 以 PP2A 为靶点进行癌症治疗调控。  |  Ronk, H., et al. 2022. Cancer Biol Med. 19: 1428-39. PMID: 36342229
  7. 蛋白磷酸酶-1 的核抑制剂 NIPP-1 的分子克隆揭示了其与参与 RNA 处理的多肽的同源性。  |  Van Eynde, A., et al. 1995. J Biol Chem. 270: 28068-74. PMID: 7499293
  8. 丝氨酸/苏氨酸蛋白磷酸酶。  |  Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
  9. 新型蛋白磷酸酶对丝氨酸和苏氨酸残基去磷酸化的重要作用  |  Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
  10. 平滑肌肌球蛋白结合磷酸酶的调节亚基。  |  Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
  11. 蛋白磷酸酶 2A 72 kDa 调节亚基的结构和表达。替代剪接产生不同大小形式的证据。  |  Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
  12. 蛋白丝氨酸/苏氨酸磷酸酶:结构, 调节和在细胞生长中的功能。  |  Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923

订购信息

产品名称产品编号规格价格数量收藏夹

PP2A-Aα/β 抗体 (4G7)

sc-13600
100 µg/ml
$316.00

PP2A-Aα/β (4G7): m-IgG Fc BP-HRP 套装

sc-526567
100 µg Ab; 10 µg BP
$354.00

PP2A-Aα/β (4G7): m-IgG1 BP-HRP 套装

sc-531940
100 µg Ab; 20 µg BP
$354.00

PP2A-Aα/β 抗体 (4G7) AC

sc-13600 AC
500 µg/ml, 25% agarose
$416.00

PP2A-Aα/β 抗体 (4G7) HRP

sc-13600 HRP
200 µg/ml
$316.00

PP2A-Aα/β 抗体 (4G7) FITC

sc-13600 FITC
200 µg/ml
$330.00

PP2A-Aα/β 抗体 (4G7) PE

sc-13600 PE
200 µg/ml
$343.00

PP2A-Aα/β 抗体 (4G7) Alexa Fluor® 488

sc-13600 AF488
200 µg/ml
$357.00

PP2A-Aα/β 抗体 (4G7) Alexa Fluor® 546

sc-13600 AF546
200 µg/ml
$357.00

PP2A-Aα/β 抗体 (4G7) Alexa Fluor® 594

sc-13600 AF594
200 µg/ml
$357.00

PP2A-Aα/β 抗体 (4G7) Alexa Fluor® 647

sc-13600 AF647
200 µg/ml
$357.00

PP2A-Aα/β 抗体 (4G7) Alexa Fluor® 680

sc-13600 AF680
200 µg/ml
$357.00

PP2A-Aα/β 抗体 (4G7) Alexa Fluor® 790

sc-13600 AF790
200 µg/ml
$357.00

I am using PP2A-Aα/β (4G7): sc-13600 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Germaine
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_8, d_27, h_4CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_13600, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 96ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from This antibody worked wellWe tried this antibody with human dermal fibroblast. It worked very well!
Date published: 2020-06-16
Rated 5 out of 5 by from Worked well!We used this antibody for western blotting with Rat cells and it worked well.
Date published: 2018-10-22
Rated 5 out of 5 by from This antibody works very wellI detect the PP2A-A in mouse kidney using this antibody diluted in 3% BSA by 1:1000, and the band is bright at 55kd. And its specificity is very good, no other band.
Date published: 2017-10-20
Rated 3 out of 5 by from AverageI've tried the free sample sc-13600 for WB,and It got a fair result.The signal is not very strong .
Date published: 2017-07-14
Rated 5 out of 5 by from Well done!the PP2A-A alpha / beta antibody has a nice bind and its site is exactly in what it should be.
Date published: 2017-03-24
Rated 5 out of 5 by from Excellent immunoperoxidase cytoplasmic stainingExcellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
Date published: 2015-05-18
Rated 5 out of 5 by from Published good quality flow cytometry dataPublished good quality flow cytometry data in jurkat T cells. -SCBT Publication Review
Date published: 2015-05-06
Rated 4 out of 5 by from Strong signal with some background for WBStrong signal with some background for WB in SW480 (A) and T-47D (B) whole cell lysates. -SCBT QC
Date published: 2015-03-21
  • y_2025, m_8, d_27, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_10
  • loc_zh_CN, sid_13600, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
PP2A-Aα/β 抗体 (4G7) is rated 4.7 out of 5 by 10.
  • y_2025, m_8, d_27, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_10
  • loc_zh_CN, sid_13600, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 100ms
  • REVIEWS, PRODUCT