podoplanin Antibody (18H5): sc-59347

Podoplanin Antibody (18H5) is a mouse monoclonal IgG antibody raised against the full-length human podoplanin protein, detecting podoplanin of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Podoplanin, also known as glycoprotein 38 (gp38), T1-alpha, Aggrus, or PA2.26 antigen, is a type I transmembrane sialoglycoprotein expressed in various tissues, including lymphatic endothelial cells, podocytes in the kidney, alveolar type I cells in the lung, and certain tumors. Podoplanin plays a crucial role in lymphangiogenesis, platelet aggregation, cell migration, and maintenance of the unique shape of podocytes, which are essential for the kidney′s filtration function. Podoplanin expression alterations are associated with pathological conditions such as cancer metastasis, lymphatic disorders, and kidney diseases like minimal change nephropathy. In the rat model of puromycin aminonucleoside nephrosis (PAN), severe proteinuria correlates with reduced expression of podoplanin, highlighting podoplanin′s importance in renal physiology. Podoplanin′s interaction with the C-type lectin-like receptor 2 (CLEC-2) on platelets is crucial for normal blood-lymphatic vessel separation during embryonic development.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-podoplanin Antibody (18H5) has 21 citations in a variety of scientific publications.

Primary antibodies like Anti-podoplanin Antibody (18H5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

podoplanin Antibody (18H5) Specifications

Alternate Product Name: podoplanin

Product Clone Name: 18H5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: podoplanin

Epitope Species: human

Product Reactivity/Detection: podoplanin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 21 citations in various scientific publications

Available Conjugates/Forms for podoplanin Antibody (18H5): N/A

The preferred podoplanin antibody is podoplanin Antibody (8.1.1): sc-53533.