Date published: 2026-10-17

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PKM 抗体 (YY-3): sc-100538

5.0(3)
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说明书
  • PKM 抗体 YY-3 是小鼠单克隆 IgM, 在2篇文献中引用,提供 200 µl ascites
  • 免疫human物种的重组PKM
  • 推荐用于 mouse, rat 和 human 来源的PKM WB, IP 和 ELISA检测
  • 看 PKM (C-11): sc-365684,可查看有标记的 PKM 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成PKM 抗体 (YY-3)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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PKM抗体(YY-3)是一种IgM小鼠单克隆PKM抗体(也称为PKM抗体或丙酮酸激酶M1/2抗体),可通过WB、IP和ELISA检测小鼠、大鼠和人类来源的PKM。PKM抗体(YY-3)为非偶联抗PKM抗体形式。在哺乳动物中,丙酮酸激酶存在四种不同的同工酶。根据其组织分布,这些同工酶被指定为L型(主要在肝脏中表达)、R型(主要在红细胞中表达)、M1型(主要在肌肉、大脑和心脏中表达)和M2型(主要在胎儿组织中表达)。丙酮酸激酶负责催化糖酵解的最后一步:将磷酸烯醇式丙酮酸转化为丙酮酸,同时生成ATP。PKM(丙酮酸激酶,肌肉)基因通过选择性剪接事件编码M1型和M2型同工酶。M1型和M2型异构体均以四聚体形式存在,并受果糖1,6-二磷酸的刺激。此外,两种异构体均表现出甲状腺激素结合活性,可称为CTHBP(胞质甲状腺激素结合蛋白)或THBP1。M2型异构体还通过其C端结构域与Oct-4相互作用,从而增强Oct-4的转录活性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PKM 抗体 (YY-3) 参考文献:

  1. 通过PKM和PEPCK的乙酰化调节糖酵解和糖异生。  |  Xiong, Y., et al. 2011. Cold Spring Harb Symp Quant Biol. 76: 285-9. PMID: 22096030
  2. 基于ASO的PKM剪接开关疗法抑制肝癌生长。  |  Ma, WK., et al. 2022. Cancer Res. 82: 900-915. PMID: 34921016
  3. Linc-UROD稳定ENO1和PKM,以增强胰腺癌细胞的糖酵解、增殖和迁移。  |  He, Y., et al. 2023. Transl Oncol. 27: 101583. PMID: 36413861
  4. PKM在角质细胞稳态和病理生理学中发挥的新作用。  |  Demeter, JB., et al. 2023. FEBS J. 290: 2311-2319. PMID: 36541050
  5. CD28-ARS2轴驱动的PKM选择性剪接可引发CD8+ T细胞代谢灵活性,从而支持抗肿瘤免疫。  |  Holling, GA., et al. 2024. Cell Mol Immunol. 21: 260-274. PMID: 38233562
  6. LINC01852通过抑制SRSF5介导的PKM选择性剪接,抑制结直肠癌的肿瘤发生和耐药性。  |  Bian, Z., et al. 2024. Mol Cancer. 23: 23. PMID: 38263157
  7. 肿瘤进展中调节PKM选择性剪接的hnRNPs调控网络。  |  Li, Y., et al. 2024. Biomolecules. 14: PMID: 38785973
  8. N6-甲基腺苷修饰的SRPK1通过PKM剪接促进肺腺癌的有氧糖酵解。  |  Wang, A., et al. 2024. Cell Mol Biol Lett. 29: 106. PMID: 39095708
  9. HNRNPC通过m6A甲基化调节PKM的替代性剪接,上调PKM2的表达,从而促进甲状腺乳头状癌的有氧糖酵解并推动恶性进展。  |  Rong, S., et al. 2024. J Transl Med. 22: 914. PMID: 39380010
  10. SARS-CoV-2核衣壳蛋白与YBX1的相互作用通过PKM mRNA的失稳表现出溶瘤特性。  |  Chen, X., et al. 2024. Mol Cancer. 23: 248. PMID: 39506849

订购信息

产品名称产品编号规格价格数量收藏夹

PKM 抗体 (YY-3)

sc-100538
200 µl ascites
$339.00

Is specific for PKM2? recognize also PKM1? Thanks

Asked by: Maia
Thank you for your question. This mouse IgM is specific for PKM, pyruvate kinase, muscle, also designated PKM2, protein accession number P14618.
Answered by: Technical Support
Date published: 2019-02-05

What is the concentration of PKM2 (YY-3): sc-100538 monoclonal antibody?

Asked by: TinTin
Thank you for your question. The concentration of PKM2 (YY-3): sc-100538 has not been characterized. We provide this antibody as 200 µl of ascites.
Answered by: Technical Support
Date published: 2017-03-24
  • y_2026, m_10, d_17, h_10CST
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Rated 5 out of 5 by JM from Performed well in WB in Jurkat whole cell lysatePerformed well in WB in Jurkat whole cell lysate. -SCBT QC
Date published: 2015-03-19
Rated 5 out of 5 by JM from Strong band of interest observed in WB inStrong band of interest observed in WB in HeLa whole cell lysate. -SCBT QC
Date published: 2015-03-19
Rated 5 out of 5 by LF from Good specificity in WB in KGood specificity in WB in K-562 whole cell lysate. -SCBT QC
Date published: 2014-12-08
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PKM 抗体 (YY-3) is rated 5.0 out of 5 by 3.
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