Date published: 2025-9-6
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PGC-1β Antibody (E-9) - Western Blotting - Image 363273
PGC-1β 抗体 (E-9) HRP: sc-373771 HRP. 对 Sol8 (A) 和 KNRK (B) 核提取物, KNRK 全细胞裂解液 (C) 以及大鼠脑 (D) 和小鼠脑 (E) 组织提取物中 PGC-1β 的表达进行直接 Western 印迹分析.
PGC-1β 抗体 (E-9) HRP: sc-373771 HRP. 对 Sol8 (A) 和 KNRK (B) 核提取物, KNRK 全细胞裂解液 (C) 以及大鼠脑 (D) 和小鼠脑 (E) 组织提取物中 PGC-1β 的表达进行直接 Western 印迹分析.

PGC-1β 抗体 (E-9): sc-373771

4.9(12)
寫評論提問

说明书
  • PGC-1 beta 抗体 E-9 是小鼠单克隆 IgG2a κ，PGC-1β抗体, 在24篇文献中引用，规格为200 µg/ml
  • 针对mouse起源的PGC-1β内部区域内的氨基酸452-593进行
  • PGC-1 beta 抗体 (E-9) 推荐用于 WB, IP, IF 和 ELISA，检测mouse 和rat 来源的 PGC-1β
  • 抗PGC-1 beta抗体（E-9）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-373771 X, 200 µg/0.1 ml)
  • 关于如何获取PGC-1β (E-9): sc-373771的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是PGC-1β Antibody (E-9) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与PGC-1β Antibody (E-9) 打包提供（请参阅下面的订购信息）。

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相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外PGC抗体，包括PGC-1 β

PGC-1β抗体（E-9）是一种IgG2a κ小鼠单克隆PGC-1 beta抗体（也称为PRGC2抗体、PPARG共激活因子1 Beta抗体、PGC1B抗体、PERC抗体、过氧化物酶体增殖物激活受体Gamma共激活因子1 Beta抗体、PPAR-Gamma共激活因子1-Beta抗体、PPARgamma共激活因子1 Beta抗体、PPARGC-1-Beta抗体、过氧化物酶体增殖激活受体Gamma共激活因子1 Beta抗体、PGC-1(Beta)抗体、PGC-1-Beta抗体、PPARGC1B抗体、PPARGC1抗体或PGC1抗体），可通过WB、IP、IF和ELISA检测小鼠和大鼠来源的PGC-1 beta蛋白。PGC-1β抗体（E-9）既可以是非偶联的抗PGC-1 beta抗体形式，也可以是多种偶联形式的抗PGC-1 beta抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。转录因子通过与共激活因子或共抑制因子蛋白结合来发挥其作用。共激活因子复合物被认为具有组成性活性，仅需要在基因组中进行适当的定位即可启动转录。共激活因子包括具有组蛋白乙酰转移酶（HAT）活性的类固醇受体共激活因子（SRC）和CREB结合蛋白（CBP）家族，这些酶可以修饰染色质结构。PPAR gamma共激活因子-1β（PGC-1β），也称为PERC或PPARGC1B，可作为NRF-1（核呼吸因子-1）、ERα（雌激素受体alpha）和GR（糖皮质激素受体）的转录激活因子。通过与各种受体的相互作用，PGC-1β参与调节线粒体生成事件，如能量消耗和非氧化性葡萄糖代谢。PGC-1β在全身表达，其中在脑、心脏和骨骼肌中的表达量最高，可被胰岛素诱导，被饱和脂肪酸抑制。编码PGC-1β的基因具有多态性，所表达的蛋白质变异可能有助于肥胖症的发展。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PGC-1β 抗体 (E-9) 参考文献:

  1. PGC-1 相关蛋白 PERC 是雌激素受体 alpha 的选择性辅激活剂。  |  Kressler, D., et al. 2002. J Biol Chem. 277: 13918-25. PMID: 11854298
  2. 过氧化物酶体增殖激活受体辅激活剂-1α（PGC-1α）可辅激活心脏丰富的核受体雌激素相关受体-α和-gamma。在 PGC-1alpha 中发现新的富含亮氨酸的相互作用基序。  |  Huss, JM., et al. 2002. J Biol Chem. 277: 40265-74. PMID: 12181319
  3. 激活孤核组成型雄烷受体需要过氧化物酶体增殖激活受体γ辅助激活剂-1 α的核下靶向作用。异生物反应与营养状况之间可能存在联系。  |  Shiraki, T., et al. 2003. J Biol Chem. 278: 11344-50. PMID: 12551939
  4. 辅激活因子 PGC-1beta 的遗传变异与肥胖之间存在关联的证据。  |  Andersen, G., et al. 2005. J Med Genet. 42: 402-7. PMID: 15863669
  5. 脂肪酸诱导体外分化的人类骨骼肌细胞中过氧化物酶体增殖激活受体-γ辅助激活剂-1α和-1β编码基因的不同调控。  |  Staiger, H., et al. 2005. Diabetologia. 48: 2115-8. PMID: 16132959
  6. 雌激素受体辅激活剂 PPARGC1A, PPARGC1B 和 EP300 的遗传变异与家族性乳腺癌的缔合作用。  |  Wirtenberger, M., et al. 2006. Carcinogenesis. 27: 2201-8. PMID: 16704985
  7. 过氧化物酶体增殖体激活受体-γ辅助激活因子-1与胰岛素抵抗：脂肪酸的急性效应。  |  Hoeks, J., et al. 2006. Diabetologia. 49: 2419-26. PMID: 16896940
  8. 过氧化物酶体增殖体活化受体伽马辅激活子 1 辅激活子, 能量平衡和新陈代谢。  |  Handschin, C. and Spiegelman, BM. 2006. Endocr Rev. 27: 728-35. PMID: 17018837
  9. PGC-1alpha/beta 的上调与携带无意义 mtDNA 突变的细胞中氧化磷酸化的改善缔合作用。  |  Srivastava, S., et al. 2007. Hum Mol Genet. 16: 993-1005. PMID: 17341490
  10. PGC-1beta：一种协同激活剂，可为基础线粒体活性和应激刺激线粒体活性定调。  |  Lelliott, CJ. and Vidal-Puig, A. 2009. Adv Exp Med Biol. 646: 133-9. PMID: 19536672
  11. PGC-1β 可调节他汀类药物导致的小鼠肌毒性。  |  Singh, F., et al. 2019. Arch Toxicol. 93: 487-504. PMID: 30511338
  12. FOXO1 可抑制骨骼肌中 PGC-1β 基因的表达。  |  Nakai, S., et al. 2020. FEBS Open Bio. 10: 1373-1388. PMID: 32433820

订购信息

产品名称产品编号规格价格数量收藏夹

PGC-1β 抗体 (E-9)

sc-373771
200 µg/ml
$316.00

PGC-1β (E-9): m-IgG Fc BP-HRP 套装

sc-529559
200 µg Ab; 10 µg BP
$354.00

PGC-1β (E-9): m-IgGκ BP-HRP 套装

sc-522493
200 µg Ab, 40 µg BP
$354.00

PGC-1β (E-9): m-IgG2a BP-HRP 套装

sc-547330
200 µg Ab; 10 µg BP
$354.00

PGC-1β 抗体 (E-9) X

sc-373771 X
200 µg/0.1 ml
$316.00

PGC-1β 抗体 (E-9) AC

sc-373771 AC
500 µg/ml, 25% agarose
$416.00

PGC-1β 抗体 (E-9) HRP

sc-373771 HRP
200 µg/ml
$316.00

PGC-1β 抗体 (E-9) FITC

sc-373771 FITC
200 µg/ml
$330.00

PGC-1β 抗体 (E-9) PE

sc-373771 PE
200 µg/ml
$343.00

PGC-1β 抗体 (E-9) Alexa Fluor® 488

sc-373771 AF488
200 µg/ml
$357.00

PGC-1β 抗体 (E-9) Alexa Fluor® 546

sc-373771 AF546
200 µg/ml
$357.00

PGC-1β 抗体 (E-9) Alexa Fluor® 594

sc-373771 AF594
200 µg/ml
$357.00

PGC-1β 抗体 (E-9) Alexa Fluor® 647

sc-373771 AF647
200 µg/ml
$357.00

PGC-1β 抗体 (E-9) Alexa Fluor® 680

sc-373771 AF680
200 µg/ml
$357.00

PGC-1β 抗体 (E-9) Alexa Fluor® 790

sc-373771 AF790
200 µg/ml
$357.00

Hello, I'm interested in your PGC-1beta antibody (E9);sc-373771. Can I have the 10ug free sample?

Asked by: Tomoki
Thank you for the question. Please contact us by email to customercare @ scbt.com and provide your full shipping address and we will be happy to send you a PGC-1β (E-9): sc-373771 Sample size.
Answered by: Technical Support Europe
Date published: 2017-12-29

I am using human epithelial cells. But i m not able to get a proper band with this antibody. Can you suggest a possible protocol for the same for a human cell line. Kindly help me out with this issue?

Asked by: Aloysius
Thank you for your product review. We are sorry to hear that this antibody did not perform for you as expected. We want you to be successful in your research. Please contact our Technical Service Department by phone, e-mail or live chat. Alternatively, you can contact our local distributor in India, https://www.scbt.com/scbt/resources/distributors. Here is a link to the recommended protocol for this antibody. https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting We are happy to help you troubleshoot the antibody. Santa Cruz Biotechnology does warranty our antibodies for one year from the date of purchase. If we are unable to successfully troubleshoot your application we will send you a replacement antibody free of charge, or issue a credit or refund if that is not possible.
Answered by: Tech Service
Date published: 2017-02-17

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 10
Date published: 2017-01-19
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Rated 5 out of 5 by from very good for westernIt detects a strong western band for mouse protein from tissue extract at 1:1000 dilution, 3% BSA, PBST.
Date published: 2017-11-03
Rated 5 out of 5 by from Great antibody for WBI test this antibody with Liver cells and the results are very nice, strong, clear signal; 1:500
Date published: 2017-10-29
Rated 5 out of 5 by from Good featuresI bought this a week ago, I did Western Blot(dilution 1:100), but one band is unclear
Date published: 2017-07-18
Rated 5 out of 5 by from Works well in cultured myotubeProduced great WB data in C2C12 myotube, no non-specific bands.
Date published: 2017-05-11
Rated 4 out of 5 by from Detects the protein well in mouse muscleWB, 5% milk in TBST. 1:1000. Though there are some non-specific bands, the target protein is easily identifiable. Better results were obtained from cultured myotubes.
Date published: 2017-05-09
Rated 5 out of 5 by from Great productVery nice western blot data; strong, clear signal; also positive IHC staining
Date published: 2017-02-03
Rated 5 out of 5 by from Good WB data with Mouse liverI bought this antibody and used it 1：1000 for Western Blotting，I got the wonderful band
Date published: 2017-01-13
Rated 5 out of 5 by from Excellent!This antibody works great in western blot analysis of PGC-1β expression in KNRK whole cell lysate.
Date published: 2017-01-12
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PGC-1β抗体 (E-9) is rated 4.9 out of 5 by 12.
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