m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for PCAF Antibody (E-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with PCAF Antibody (E-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PCAF Antibody (E-8) is a high quality monoclonal PCAF antibody (also designated P300/CBP-associated factor antibody, CAF antibody, PCAF antibody, P/CAF antibody, CBP / p300 binding protein antibody, histone acetyl transferase antibody, or lysine (K) acetyltransferase 2B antibody) suitable for the detection of the PCAF protein of mouse, rat and human origin. PCAF Antibody (E-8) is available as both the non-conjugated anti-PCAF antibody form, as well as multiple conjugated forms of anti-PCAF antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessiblity to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1) and HDAC2 (also designated mammalian RPD3), both of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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