Date published: 2025-9-6

021-6093-6350

SCBT Portrait Logo
Seach Input

p-Ras GAP 抗体 (pY460.19A): sc-136481

5.0(2)
寫評論提問

说明书
  • p-Ras GAP抗体(pY460.19A)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为200 µg/ml
  • 针对human起源的Ras GAP的含磷酸化Tyr 460的短氨基酸序列
  • 推荐用于 Tyr 460 phosphorylated Ras GAP of human origin and Tyr 451 phosphorylated Ras GAP of mouse and rat origin WB 和 IP检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是p-Ras GAP Antibody (pY460.19A) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与p-Ras GAP Antibody (pY460.19A) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

哺乳动物c-H-、c-K-和N-Ras原癌基因编码普遍表达的蛋白质。p21Ras可以存在于生理静止的GDP结合状态或GTP结合信号发射状态。致癌p21Ras蛋白被困在兴奋的信号发射状态,因为通常用于限定其兴奋期的机制,即其结合的GTP水解为GDP,因特定突变而受损。p21Ras与GTP酶激活蛋白(GAP)的相互作用可以增加p21Ras结合的GTP的水解,高达1000倍。1型神经纤维瘤病基因(NF1)的产物也显示出p21Ras GAP活性,并且已经描述了刺激其他三种低分子量GTP酶(包括Rho、Rab 3A和Rap 1)的GTP酶活性的蛋白质。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p-Ras GAP 抗体 (pY460.19A) 参考文献:

  1. Bcr 编码 p21rac 的 GTPase 激活蛋白。  |  Diekmann, D., et al. 1991. Nature. 351: 400-2. PMID: 1903516
  2. 克雷夫-1 蛋白 p21rap1 特异性 GTPase 激活蛋白的分子克隆。  |  Rubinfeld, B., et al. 1991. Cell. 65: 1033-42. PMID: 1904317
  3. 神经纤维瘤病 1 型基因产物的 GAP 相关结构域与 ras p21 相互作用。  |  Martin, GA., et al. 1990. Cell. 63: 843-9. PMID: 2121370
  4. NF1 基因座编码一种在功能上与哺乳动物 GAP 和酵母 IRA 蛋白相关的蛋白质。  |  Ballester, R., et al. 1990. Cell. 63: 851-9. PMID: 2121371
  5. eEF2和Ras-GAP SH3结构域结合蛋白(G3BP1)在HIV-1感染期间调节应激颗粒的组装。  |  Valiente-Echeverría, F., et al. 2014. Nat Commun. 5: 4819. PMID: 25229650
  6. ras GTPase 激活蛋白:信号传递者和信号终结者。  |  McCormick, F. 1989. Cell. 56: 5-8. PMID: 2535967
  7. 牛 GAP 的克隆及其与致癌基因 ras p21 的相互作用。  |  Vogel, US., et al. 1988. Nature. 335: 90-3. PMID: 2842690
  8. 黑色素瘤细胞中 IQGAP1 的 Ras GAP 相关和 C 端结构域依赖性定位及致瘤活性。  |  Reimer, M., et al. 2017. PLoS One. 12: e0189589. PMID: 29240845
  9. 从人类胎盘中分子克隆出两种类型的 GAP 互补 DNA。  |  Trahey, M., et al. 1988. Science. 242: 1697-700. PMID: 3201259
  10. ras 基因。  |  Barbacid, M. 1987. Annu Rev Biochem. 56: 779-827. PMID: 3304147
  11. 与哈维鼠肉瘤病毒 p21src 蛋白相关的鸟嘌呤核苷酸结合和自身磷酸化活性。  |  Shih, TY., et al. 1980. Nature. 287: 686-91. PMID: 6253810
  12. Sam68 是有丝分裂过程中的一种 Ras-GAP 相关蛋白。  |  Guitard, E., et al. 1998. Biochem Biophys Res Commun. 245: 562-6. PMID: 9571195

订购信息

产品名称产品编号规格价格数量收藏夹

p-Ras GAP 抗体 (pY460.19A)

sc-136481
200 µg/ml
$316.00

p-Ras GAP (pY460.19A): m-IgG Fc BP-HRP 套装

sc-537378
200 µg Ab; 10 µg BP
$354.00

p-Ras GAP (pY460.19A): m-IgGκ BP-HRP 套装

sc-534629
200 µg Ab; 40 µg BP
$354.00

p-Ras GAP (pY460.19A): m-IgG1 BP-HRP 套装

sc-545164
200 µg Ab; 20 µg BP
$354.00

Are there any issues with using sc-136481: p-Ras GAP (pY460.19A) mouse monoclonal primary antibody on mouse samples?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-136481 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
  • y_2025, m_8, d_28, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_136481, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 102ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from what is we monitorWe can monitor that the oncogenic p21Ras proteins are captured in the excited signal-emitting state, since the mechanism usually used to define their excitation phase, the bound GTP hydrolysates to GDP and is impaired due to specific mutations.
Date published: 2017-02-08
Rated 5 out of 5 by from Good specificity and single strength forGood specificity and single strength for WB in untreated and alkaline phosphatase-treated RSV-3T3 cells. - SCBT QC
Date published: 2014-05-31
  • y_2025, m_8, d_28, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_136481, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 12ms
  • REVIEWS, PRODUCT
p-Ras GAP 抗体 (pY460.19A) is rated 5.0 out of 5 by 2.
  • y_2025, m_8, d_28, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_136481, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 140ms
  • REVIEWS, PRODUCT