p-ErbB2/HER2 Antibody (12B9): sc-81505
- p-ErbB2/HER2 Antibody (12B9) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against phosphopeptide corresponding to amino acid residues surrounding tyrosine 877 of Neu of human origin
- recommended for detection of Tyr 877 phosphorylated Neu of human origin, Tyr 878 phosphorylated Neu of mouse origin, and Tyr 879 phosphorylated Neu of rat origin. by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-ErbB2/HER2 Antibody (12B9). This work is in progress.
QUICK LINKS
SEE ALSO...
p-Neu Antibody (12B9) is a mouse monoclonal IgG1 antibody that detects Neu in mouse, rat, and human samples through western blotting (WB). p-Neu (12B9) antibody specifically recognizes phosphorylated forms of Neu, which is crucial for understanding Neu′s role in various cellular processes, particularly in cancer biology. Neu, also known as HER2, is a member of the ErbB family of receptor tyrosine kinases and plays a significant role in cell signaling pathways that regulate cell growth, differentiation, and survival. Neu is primarily located at the cell membrane, where Neu interacts with other proteins to form signaling complexes that can lead to oncogenic transformations. Notably, Neu phosphorylation at specific tyrosine residues, such as Tyr 1248, is essential for Neu interaction with the Mucin4/Sialomucin complex, which is localized at the apical surfaces of ductal and alveolar cells in the lactating gland. This localization influences signaling pathways that contribute to the development and progression of certain cancers, including breast, gastric, and esophageal cancers. Using anti-Neu antibody (12B9) in research can provide valuable insights into Neu signaling mechanisms and implications in tumorigenesis, making anti-Neu antibody (12B9) an indispensable tool for cancer research and therapeutic development.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-ErbB2/HER2 Antibody (12B9) | sc-81505 | 50 µg/0.5 ml | $322.00 |