p-NFKBIA/IkB alpha Antibody (39A1431): sc-52943
- p-NFKBIA/IkB alpha Antibody (39A1431) is a mouse monoclonal IgG1 κ, cited in 25 publications, provided at 50 µg/0.5 ml
- raised against synthetic peptide containing phosphorylated serines at amino acid residues 32 and 36 of p-IκB-α of human origin
- recommended for detection of Ser 32 and Ser 36 phosphorylated IκB-α of mouse, rat and human origin by WB
- See p-NFKBIA/IkB alpha (B-9): sc-8404 for p-NFKBIA/IkB alpha antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-NFKBIA/IkB alpha Antibody (39A1431). This work is in progress.
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p-IκB-α Antibody (39A1431) is a mouse monoclonal IgG1 antibody that detects p-IκB-α in mouse, rat, and human samples through western blotting (WB). p-IκB-α plays a crucial role in regulating the NF-κB signaling pathway, which controls various cellular processes, including inflammation, immune response, and cell survival. Phosphorylation of IκB-α leads to inhibitor degradation, allowing NF-κB dimers to translocate to the nucleus and activate target genes. This post-translational modification enables timely and appropriate responses to cellular stress and inflammatory signals, making p-IκB-α a key player in maintaining cellular homeostasis. p-IκB-α (39A1431) monoclonal antibody provides reliable detection of phosphorylated IκB-α, enabling researchers to study its role in various biological contexts and disease states, particularly those related to dysregulated NF-κB activity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-NFKBIA/IkB alpha Antibody (39A1431) References:
- NF-kappaB activation and IkappaB alpha dynamism involved in iNOS and chemokine induction in astroglial cells. | Nomura, Y. 2001. Life Sci. 68: 1695-701. PMID: 11270616
- [Effect of TLR4 on expressions of p-IRAK1 and p-IkappaB-alpha in HPDLCs stimulated by lipopolysaccharide]. | Sun, Y., et al. 2007. Shanghai Kou Qiang Yi Xue. 16: 632-5. PMID: 18278418
- COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization. | Taura, M., et al. 2015. J Virol. 89: 2643-58. PMID: 25520503
- Detection of IκB degradation dynamics and IκB-α ubiquitination. | Starokadomskyy, P. and Burstein, E. 2015. Methods Mol Biol. 1280: 15-24. PMID: 25736741
- Z-guggulsterone negatively controls microglia-mediated neuroinflammation via blocking IκB-α-NF-κB signals. | Huang, C., et al. 2016. Neurosci Lett. 619: 34-42. PMID: 26879835
- Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB. | Chen, S., et al. 2017. J Am Chem Soc. 139: 14098-14108. PMID: 28898075
- CEACAM1 Inhibited IκB-α/NF-κB Signal Pathway Via Targeting MMP-9/TIMP-1 Axis in Diabetic Atherosclerosis. | Yu, J., et al. 2020. J Cardiovasc Pharmacol. 76: 329-336. PMID: 32569018
- ROS-Induced Hepatotoxicity under Cypermethrin: Involvement of the Crosstalk between Nrf2/Keap1 and NF-κB/iκB-α Pathways Regulated by Proteasome. | Zhao, H., et al. 2021. Environ Sci Technol. 55: 6171-6183. PMID: 33843202
- SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α. | Cui, X., et al. 2022. Cell Oncol (Dordr). 45: 69-84. PMID: 34855159
- Diagnosis of IRAK-4-deficiency by flow cytometric measurement of IκB-α degradation. | Frans, G., et al. 2024. Clin Chem Lab Med. 62: e102-e105. PMID: 37929815
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-NFKBIA/IkB alpha Antibody (39A1431) | sc-52943 | 50 µg/0.5 ml | $322.00 |