p-EGFR Antibody (3F2): sc-57544

p-EGFR Antibody (3F2) is a mouse monoclonal IgG1 antibody that detects epidermal growth factor receptor (EGFR) in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). anti-EGFR antibody (3F2) is raised against a synthetic phosphopeptide of EGFR of human origin to specifically recognize phosphorylated forms of EGFR, which is crucial for understanding cell signaling pathways that regulate cell growth and differentiation. EGFR is primarily located on the cell surface, where EGFR functions as a receptor for epidermal growth factors, mediating critical cellular responses upon ligand binding. This localization allows EGFR to initiate signaling cascades that influence various physiological processes, including cell proliferation, survival, and migration. Dysregulation of EGFR signaling is implicated in numerous cancers, making EGFR an important target for therapeutic intervention. Phosphorylation of specific tyrosine residues on EGFR, such as Tyr 1092 and Tyr 1173, is essential for activation and subsequent downstream signaling, highlighting the importance of monitoring these modifications in research and clinical settings. EGFR monoclonal antibody (3F2) enables researchers to gain insights into the functional status of EGFR and involvement in disease mechanisms, thereby advancing understanding of targeted therapies in oncology.

The preferred EGFR antibody is EGFR Antibody (528): sc-120.