NKHC1 Antibody (D-3): sc-398759

NKHC1 Antibody (D-3) is a mouse monoclonal IgM antibody that detects NKHC1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NKHC1, also known as KIF5A or kinesin family member 5A, plays a crucial role as a neuronal-specific component of a multi-subunit molecular motor complex responsible for intracellular organelle transport, which is vital for maintaining neuronal function and health. Mutations in the gene encoding NKHC1 are linked to autosomal dominant spastic paraplegia 10, a neurodegenerative disorder characterized by progressive weakness and stiffness of the legs. NKHC1 exhibits a pan-neuronal distribution within the nervous system, with expression particularly enriched in subsets of neurons, highlighting importance in neuronal transport processes. In cultured hippocampal neurons, NKHC1 is notably concentrated in the perinuclear region of the cell body, indicating involvement in the transport of cellular components necessary for neuronal maintenance and signaling. NKHC1′s ability to convey cargo along microtubules, as part of the kinesin superfamily proteins, underscores significance in the intricate network of neuronal communication and function, making anti-NKHC1 antibody (D-3) an invaluable tool for researchers studying neuronal dynamics and related pathologies.

The preferred NKHC1 antibody is NKHC1 Antibody (C-11): sc-376452.