Mucin 1/MUC1 Antibody (H-6): sc-25274

Mucin 1 Antibody (H-6) is a mouse monoclonal IgG2a antibody that detects Mucin 1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Mucin 1 plays a crucial role in cell signaling and adhesion, acting as a protective barrier on epithelial surfaces and contributing to the maintenance of tissue integrity. Mucin 1′s aberrant expression is particularly significant in epithelial tumors, such as breast carcinomas, where anti-Mucin 1 antibody (H-6) can help study tumor progression and metastasis. Mucin 1′s structure, characterized by a variable number of tandem repeats, allows for extensive glycosylation, which is essential for function in cell-cell interactions and immune evasion. Mucin 1′s unique structural features not only facilitate a role in normal physiological processes but also underscore potential as a biomarker for cancer diagnosis and prognosis, making Mucin 1 (H-6) antibody an invaluable tool for researchers studying tumor biology and therapeutic targets.

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Mucin 1/MUC1 Antibody (H-6) References:

1. Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis.  |  Liu, X., et al. 2019. Sci Rep. 9: 10656. PMID: 31337812
2. Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury.  |  Zheng, Y., et al. 2019. Cell Commun Signal. 17: 103. PMID: 31438964
3. Mucin-1 conjugated polyamidoamine-based nanoparticles for image-guided delivery of gefitinib to breast cancer.  |  Nabi, PN., et al. 2021. Int J Biol Macromol. 174: 185-197. PMID: 33516855
4. Mucin 1 regulates the hypoxia response in head and neck cancer cells.  |  Utispan, K. and Koontongkaew, S. 2021. J Pharmacol Sci. 147: 331-339. PMID: 34663515
5. Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis-Induced Acute Lung Injury through GSK3β/Keap1-Nrf2-GPX4 Pathway.  |  Wang, YM., et al. 2022. Oxid Med Cell Longev. 2022: 2405943. PMID: 35910848
6. Serum Galectin-3 and Mucin-1 (CA15-3) in Relation to Renal Function in Untreated Chinese Patients.  |  Huang, QF., et al. 2023. Am J Hypertens. 36: 176-182. PMID: 36226892
7. Cytotoxic activity of anti-mucin 1 chimeric antigen receptor T cells expressing PD-1-CD28 switch receptor against cholangiocarcinoma cells.  |  Supimon, K., et al. 2023. Cytotherapy. 25: 148-161. PMID: 36396553
8. Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas.  |  Yang, F., et al. 2023. Arch Med Sci. 19: 638-644. PMID: 37313197
9. Probing Aberrantly Glycosylated Mucin 1 in Breast Cancer Extracellular Vesicles.  |  Saroj, S., et al. 2023. ACS Appl Bio Mater. 6: 4944-4951. PMID: 37824707
10. Mucin-1-Targeted Chimeric Antigen Receptor T Cells Are Effective and Safe in Controlling Solid Tumors in Immunocompetent Host.  |  Zhou, R., et al. 2024. J Immunother. 47: 77-88. PMID: 38270462

The preferred Mucin 1/MUC1 antibody is Mucin 1/MUC1 Antibody (VU4H5): sc-7313.