Date published: 2025-9-6
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MRP4 Antibody (F-6) - Western Blotting - Image 356102
MRP4 抗体 (F-6): sc-376262. 对 HeLa (A), A549 (B), HEL 92. 1. 7 (C) 和 MDA-MB-231 (D) 全细胞裂解液中 MRP4 表达的 Western 印迹分析.
MRP4 抗体 (F-6): sc-376262. 对 HeLa (A), A549 (B), HEL 92. 1. 7 (C) 和 MDA-MB-231 (D) 全细胞裂解液中 MRP4 表达的 Western 印迹分析.

MRP4 抗体 (F-6): sc-376262

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寫評論提問

说明书
  • MRP4 抗体 F-6 是小鼠单克隆 IgG1 κ，MRP4抗体, 在6篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列1-280位于human物种的MRP4的N-terminus附近
  • MRP4 抗体 (F-6) 推荐用于WB, IP, IF, IHC(P) 和 ELISA，检测human 来源的 MRP4
  • 抗MRP4抗体（F-6）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取MRP4 (F-6): sc-376262的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是MRP4 Antibody (F-6) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与MRP4 Antibody (F-6) 打包提供（请参阅下面的订购信息）。

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関連項目

额外MRP抗体，包括MRP1, MRP2, MRP3, MRP4, MRP5和MRP6

MRP4抗体（F-6）是一种IgG1 κ小鼠单克隆MRP4抗体（也称为ABCC3抗体或MOAT-B抗体），可通过WB、IP、IF、IHC(P)和ELISA检测人源MRP4蛋白。MRP4抗体（F-6）既可以作为非偶联的抗MRP4抗体，也可以作为多种偶联形式的抗MRP4抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。在人类癌细胞中赋予多药耐药性的ABC转运蛋白大家族的两个成员是Mdr-1 P-糖蛋白和多药耐药性蛋白MRP1。MRP1是一种完整的膜蛋白，包含一个MDR样核心、一个N端膜结合区和一个细胞质连接体，它在各种脑细胞以及肺、睾丸和外周血中表达。MRP基因家族还包括MRP2，其可替换地命名为cMOAT（用于小管多特异性有机阴离子转运蛋白），以及MRP3，它们都是主要在肝细胞中表达的偶联输出泵。MRP2仅定位于心尖膜，并在正常肝细胞中以高水平组成性表达。相反，MRP3定位于基底外侧膜，在那里它还介导有机阴离子S-(2,4-二硝基苯基-)谷胱甘肽向膜的基底外侧的转运。MRP3通常以相对低于MRP2的水平表达，并且仅当MRP2通过顶膜的分泌受损时才增加。MRP6在肝脏和肾脏中高表达，而MRP4和MRP5在各种组织中检测到，但表达水平要低得多。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MRP4 抗体 (F-6) 参考文献:

  1. 定域于肝细胞基底膜的人类多药耐药蛋白同工型 MRP3 的特征。  |  König, J., et al. 1999. Hepatology. 29: 1156-63. PMID: 10094960
  2. MRP3，一种新的 ATP 结合盒蛋白，定位在肝细胞的管状结构域。  |  Ortiz, DF., et al. 1999. Am J Physiol. 276: G1493-500. PMID: 10362653
  3. 人多药抗性蛋白 2（MRP2）基因 5'-flanking 区域的特征及其与多药抗性蛋白 3（MRP3）基因的调控比较。  |  Stöckel, B., et al. 2000. Eur J Biochem. 267: 1347-58. PMID: 10691972
  4. 谷胱甘肽对过度表达多药耐药性相关蛋白的耐多药人类肺部肿瘤细胞系药物转运的调控。  |  Versantvoort, CH., et al. 1995. Br J Cancer. 72: 82-9. PMID: 7599070
  5. 肝管膜 5：MRP2（cMRP/cMOAT）基因编码的共轭物输出泵在肝脏中的表达和定域。  |  Keppler, D. and Konig, J. 1997. FASEB J. 11: 509-16. PMID: 9212074
  6. 多药耐药性相关蛋白基因（MRP1）的同源物 cMOAT (MRP2), MRP3, MRP4 和 MRP5 在人类癌细胞系中的表达分析。  |  Kool, M., et al. 1997. Cancer Res. 57: 3537-47. PMID: 9270026
  7. 缺乏 N 端跨膜结构域的功能性多药耐药蛋白（MRP1）。  |  Bakos, E., et al. 1998. J Biol Chem. 273: 32167-75. PMID: 9822694

订购信息

产品名称产品编号规格价格数量收藏夹

MRP4 抗体 (F-6)

sc-376262
200 µg/ml
$316.00

MRP4 (F-6): m-IgGκ BP-HRP 套装

sc-522899
200 µg Ab, 40 µg BP
$354.00

MRP4 (F-6): m-IgG1 BP-HRP 套装

sc-533534
200 µg Ab; 20 µg BP
$354.00

MRP4 抗体 (F-6) AC

sc-376262 AC
500 µg/ml, 25% agarose
$416.00

MRP4 抗体 (F-6) HRP

sc-376262 HRP
200 µg/ml
$316.00

MRP4 抗体 (F-6) FITC

sc-376262 FITC
200 µg/ml
$330.00

MRP4 抗体 (F-6) PE

sc-376262 PE
200 µg/ml
$343.00

MRP4 抗体 (F-6) Alexa Fluor® 488

sc-376262 AF488
200 µg/ml
$357.00

MRP4 抗体 (F-6) Alexa Fluor® 546

sc-376262 AF546
200 µg/ml
$357.00

MRP4 抗体 (F-6) Alexa Fluor® 594

sc-376262 AF594
200 µg/ml
$357.00

MRP4 抗体 (F-6) Alexa Fluor® 647

sc-376262 AF647
200 µg/ml
$357.00

MRP4 抗体 (F-6) Alexa Fluor® 680

sc-376262 AF680
200 µg/ml
$357.00

MRP4 抗体 (F-6) Alexa Fluor® 790

sc-376262 AF790
200 µg/ml
$357.00

Can antibody MRP4 (F-6) 376262 be diluted in TBS-T 0,05%?

Asked by: Simone
Thank you for your question. For applications that require blocking we recommend using UltraCruz® Blocking Reagent: sc-516214, milk TBS-T, or BSA in TBS-T as diluents. Otherwise, just TBS-T is suitable for diluting the antibody as well.
Answered by: Tech Support Europe
Date published: 2024-11-11

Hello, Our team is very interested in this Antibody. Could we have a sample to test it ? We are planing to use some more in the future. Kind regards Edris OMAR UMRS1166 - Université Pierre et Marie Curie - Sorbonne Universités - Paris

Asked by: Edris
Thank you for the question and interest in our products. Our Customer Service Dept. will contact you by email.
Answered by: Technical Support Europe
Date published: 2018-01-31

Does MRP4 (F-6): sc-376262 has any references?

Asked by: Yuval
Thank you for your question. Unfortunately we do not have an known citations for this antibody yet, however we do have nice results with it in our in house testing. It is covered under our warranty for one year from the date of purchase. If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-04-03

Can MRP4 (F-6): sc-376262 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Cweed
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, MRP4 (F-6): sc-376262 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from ExcellentProduced positive Western blot data of MRP4 expression in Basal membranes of the syncytiotrophoblast human placenta. (40ug Protein, dilution 1:50)
Date published: 2017-10-26
Rated 5 out of 5 by from ExcellentWe are testing antibodies in research, and the process to have them was simple, considering that they came directly from the USA
Date published: 2017-05-30
Rated 5 out of 5 by from Produced beautiful immunoperoxidase membraneProduced beautiful immunoperoxidase membrane staining in formalin fixed, paraffin-embedded human prostate tissue. -SCBT QC
Date published: 2015-03-01
Rated 5 out of 5 by from Produced positive Western Blot data of MRP4Produced positive Western Blot data of MRP4 expression in LNCaP whole cell lysate. -SCBT QC
Date published: 2013-07-19
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MRP4 抗体 (F-6) is rated 5.0 out of 5 by 4.
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