MRP4 Activators
Multidrug Resistance-Associated Protein 4 (MRP4) is a membrane-bound protein belonging to the ATP-binding cassette (ABC) transporter family, playing a pivotal role in cellular detoxification and maintaining intracellular homeostasis. MRP4 is widely expressed in various tissues, including the liver, kidney, intestine, and blood vessels, where it facilitates the efflux of diverse endogenous and exogenous substrates, such as cyclic nucleotides, lipids, and anticancer drugs. One of its primary functions is to regulate the intracellular levels of cyclic nucleotides, including cAMP and cGMP, by actively transporting them out of cells, thereby modulating downstream signaling pathways mediated by these second messengers. Additionally, MRP4 contributes to the elimination of xenobiotics and metabolic waste products from cells, thereby conferring protection against cytotoxicity and maintaining cellular integrity.
Activation of MRP4 involves complex regulatory mechanisms that govern its transport activity and subcellular localization. One key mechanism of MRP4 activation is post-translational modification, including phosphorylation, which can enhance its transport function and alter its interaction with binding partners. Additionally, MRP4 activation is modulated by various signaling pathways and intracellular cues. For instance, activation of protein kinase A (PKA) and protein kinase C (PKC) pathways has been shown to stimulate MRP4-mediated transport activity, possibly through direct phosphorylation of the transporter or through downstream effects on cellular signaling cascades. Furthermore, alterations in intracellular calcium levels and redox status have been implicated in regulating MRP4 activity, highlighting the intricate interplay between cellular signaling and transporter function. Overall, elucidating the mechanisms underlying MRP4 activation provides insights into its physiological roles in cellular detoxification and homeostasis, with implications for pharmacological intervention targeting multidrug resistance mechanisms.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid is an inhibitor of MRP4, which is a multidrug resistance protein. It functions by blocking the efflux of various compounds from cells, including drugs, thereby increasing their intracellular concentration. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac can indirectly affect MRP4 by potentially influencing the transport of certain compounds that are substrates of MRP4. Its exact impact on MRP4 may depend on the specific substrates and cellular context. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin can influence MRP4 activity, potentially affecting the transport of certain substrates of this transporter. Its exact mechanism and impact on MRP4 may vary depending on the specific context. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
Ibuprofen may have an indirect effect on MRP4 by potentially influencing the transport of specific compounds that are substrates of this transporter. Its impact on MRP4 can depend on the context and substrates involved. | ||||||
Diclofenac acid | 15307-86-5 | sc-357332 sc-357332A | 5 g 25 g | $107.00 $292.00 | 5 | |
Diclofenac acid can affect MRP4 activity, potentially altering the transport of certain compounds that are substrates of this transporter. The exact mechanism and impact may vary depending on specific substrates and cellular context. | ||||||
Ketoprofen | 22071-15-4 | sc-205359 sc-205359A | 5 g 25 g | $93.00 $308.00 | 2 | |
Ketoprofen can have an indirect impact on MRP4 by potentially affecting the transport of specific substrates of this transporter. The exact mechanism and consequences may depend on the particular context and substrates involved. | ||||||
Piroxicam | 36322-90-4 | sc-200576 sc-200576A | 1 g 5 g | $107.00 $369.00 | 2 | |
Piroxicam may indirectly influence MRP4 activity by potentially modulating the transport of specific compounds that are substrates of this transporter. The exact mechanism and impact can vary depending on the context and substrates involved. | ||||||
Naproxen | 22204-53-1 | sc-200506 sc-200506A | 1 g 5 g | $24.00 $40.00 | ||
Naproxen can affect MRP4 activity, potentially altering the transport of specific compounds that are substrates of this transporter. The exact mechanism and impact may vary depending on specific substrates and cellular context. | ||||||
Etoricoxib | 202409-33-4 | sc-218446 | 10 mg | $35.00 | 3 | |
Etoricoxib may have an indirect impact on MRP4 by potentially affecting the transport of specific substrates of this transporter. The exact mechanism and consequences may depend on the particular context and substrates involved. | ||||||
Vioxx | 162011-90-7 | sc-208486 | 100 mg | $190.00 | 3 | |
Vioxx can indirectly influence MRP4 activity by potentially modulating the transport of specific compounds that are substrates of this transporter. The exact mechanism and impact can vary depending on the context and substrates involved. | ||||||