Date published: 2025-9-9

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MGMT 抗体 (MT5.1): sc-33674

5.0(4)
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说明书
  • MGMT抗体(MT5.1)是小鼠单克隆IgG1 κ, 在2篇文献中引用,规格为200 µg/ml
  • 免疫human物种的重组MGMT
  • 推荐用于 human 来源的MGMT WB, IP, IF 和 IHC(P)检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 看 MGMT (E-1): sc-166528,可查看有标记的 MGMT 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 MGMT 抗体 (MT5.1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与MGMT 抗体 (MT5.1) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

MGMT(O6-甲基鸟嘌呤-DNA甲基转移酶)在DNA损伤时会被转录激活,并起到修复由致癌物或细胞抑制剂引起的致突变和细胞毒性的O6-烷基鸟嘌呤损伤的作用。在p53缺陷型小鼠中,电离辐射不会诱导MGMT的产生,这表明MGMT的诱导可能需要p53的参与。同样地,研究表明,只有在表达功能性p53的细胞系中,MGMT的mRNA和蛋白质才能被电离辐射诱导产生,而在不表达野生型p53的细胞系中则不行。相反,在对口腔癌细胞系的研究中发现,高MGMT活性与突变型p53的存在有关。类似地,与具有突变型p53的肿瘤相比,具有野生型p53的卵巢肿瘤中的MGMT活性显著降低,这支持了野生型p53下调基础MGMT启动子的观点。

仅限研究使用。不适用于诊断和治疗用途。

订购信息

产品名称产品编号规格价格数量收藏夹

MGMT 抗体 (MT5.1)

sc-33674
200 µg/ml
$316.00

MGMT (MT5.1): m-IgG Fc BP-HRP 套装

sc-536773
200 µg Ab; 10 µg BP
$354.00

MGMT (MT5.1): m-IgGκ BP-HRP 套装

sc-533937
200 µg Ab; 40 µg BP
$354.00

MGMT (MT5.1): m-IgG1 BP-HRP 套装

sc-544812
200 µg Ab; 20 µg BP
$354.00

MGMT 抗体 (MT5.1) FITC

sc-33674 FITC
200 µg/ml
$330.00

MGMT 抗体 (MT5.1) PE

sc-33674 PE
200 µg/ml
$343.00

Can MGMT (MT5.1): sc-33674 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, MGMT (MT5.1): sc-33674 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Good for IHC(P)Good localization of signal to the nucleus of of Islets of Langerhans and glandular cells in human pancreas and duodenum.
Date published: 2017-02-06
Rated 5 out of 5 by from Published western blot data obtained usingPublished western blot data obtained using human glioma cells, GBMs. -SCBT Publication Review
Date published: 2015-06-18
Rated 5 out of 5 by from StrongStrong, clean band in western blot analysis of human MGMT expression in Jurkat, MCF7 and transfected whole cell lysates. -SCBT QC
Date published: 2015-05-02
Rated 5 out of 5 by from Beautiful immunoperoxidase nuclear stainingBeautiful immunoperoxidase nuclear staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
Date published: 2015-03-11
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MGMT抗体 (MT5.1) is rated 5.0 out of 5 by 4.
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