Date published: 2025-9-6

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MFF 抗体 (B-2): sc-398617

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说明书
  • MFF 抗体 B-2 是小鼠单克隆 IgG3 κ,MFF抗体, 在16篇文献中引用,规格为200 µg/ml
  • 特定表位,MFF的细胞质域内91-117氨基酸之间的对应关系,human起源
  • 推荐用于 mouse, rat 和 human 来源的MFF WB, IP, IF 和 ELISA检测
  • 关于如何获取MFF (B-2): sc-398617免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRPm-IgGκ BP-HRP是MFF Antibody (B-2) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与MFF Antibody (B-2) 打包提供(请参阅下面的订购信息)。

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関連項目

MFF抗体(B-2)是一种IgG3 κ小鼠单克隆MFF抗体(也称为MFF抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的MFF蛋白。MFF抗体(B-2)以非共轭抗MFF抗体的形式提供。MFF(线粒体分裂因子),也被称为GL004、AD030或AD033,是一种包含342个氨基酸的单次跨膜IV型线粒体外膜蛋白,属于tango11家族。MFF参与线粒体和过氧化物酶体的分裂,在胃、心脏、肌肉、肝脏、大脑和肾脏中大量表达。MFF以五种可选剪接异构体的形式存在,这些异构体由映射到人类2号染色体2q36.3上的一个基因编码。作为第二大的人类染色体,2号染色体由2.37亿个碱基组成,编码超过1400个基因,约占人类基因组的8%。许多遗传疾病与2号染色体上的基因有关。例如,罕见的病态皮肤畸形--鱼鳞病与ABCA12基因突变有关;脂质代谢紊乱症--植物固醇血症与ABCG5和ABCG8有关;一种极为罕见的名为Alström综合征的隐性遗传病是由于ALMS1基因突变引起的。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MFF 抗体 (B-2) 参考文献:

  1. 阿尔斯特罗姆综合征:确认与染色体 2p12-13 的联系以及三个受影响兄弟姐妹的表型异质性。  |  Zumsteg, U., et al. 2000. J Med Genet. 37: E8. PMID: 10882760
  2. ABCG(White)基因亚家族的一个 ATP 结合盒基因(ABCG5)映射到人类染色体 2p21 上的 Sitosterolemia 基因座区域。  |  Shulenin, S., et al. 2001. Cytogenet Cell Genet. 92: 204-8. PMID: 11435688
  3. ALMS1 是一个编码 47 个氨基酸的大型串联重复基因,它的突变会导致阿尔斯特姆综合征。  |  Hearn, T., et al. 2002. Nat Genet. 31: 79-83. PMID: 11941370
  4. ABCA12基因突变是严重先天性皮肤病哈勒奎鱼鳞病的基础。  |  Kelsell, DP., et al. 2005. Am J Hum Genet. 76: 794-803. PMID: 15756637
  5. 新型尾锚膜蛋白Mff控制哺乳动物细胞中线粒体和过氧化物酶体的分裂。  |  Gandre-Babbe, S. and van der Bliek, AM. 2008. Mol Biol Cell. 19: 2402-12. PMID: 18353969
  6. 滤泡型甲状腺乳头状癌和典型变异型甲状腺乳头状癌中一组基因的差异表达。  |  Igci, YZ., et al. 2011. Endocr Pathol. 22: 86-96. PMID: 21509594
  7. 线粒体分裂因子(MFF)抑制线粒体代谢并降低乳腺癌干细胞(CSC)活性。  |  Sánchez-Alvarez, R., et al. 2020. Front Oncol. 10: 1776. PMID: 33194575
  8. 线粒体分裂因子(Mff)是精子细胞中线粒体鞘组织所必需的。  |  Varuzhanyan, G., et al. 2021. Biochim Biophys Acta Gen Subj. 1865: 129845. PMID: 33476744
  9. 线粒体分裂因子促进肝细胞癌对顺铂的耐药性。  |  Li, X., et al. 2022. Acta Biochim Biophys Sin (Shanghai). 54: 301-310. PMID: 35538029
  10. 线粒体分裂因子在糖尿病肾病足细胞损伤中的作用。  |  Xiao, M., et al. 2022. Biochem Biophys Res Commun. 624: 40-46. PMID: 35932578
  11. 患有线粒体分裂性脑病的斗牛獒的线粒体分裂因子(MFF)移码变异。  |  Christen, M., et al. 2022. Anim Genet. 53: 814-820. PMID: 36085405
  12. 绘制参与调节饮食胆固醇吸收的基因图谱。sitosterolemia 基因座位于染色体 2p21。  |  Patel, SB., et al. 1998. J Clin Invest. 102: 1041-4. PMID: 9727073

订购信息

产品名称产品编号规格价格数量收藏夹

MFF 抗体 (B-2)

sc-398617
200 µg/ml
$316.00

MFF (B-2): m-IgGκ BP-HRP 套装

sc-524425
200 µg Ab, 40 µg BP
$354.00

MFF (B-2): m-IgG3 BP-HRP 套装

sc-550365
200 µg Ab; 40 µg BP
$354.00

MFF (B-2) 中和勝肽

sc-398617 P
100 µg/0.5 ml
$68.00

I need to use an antibody to detect the protein in samples of avian origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 7
Date published: 2017-02-09
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Rated 4 out of 5 by from Good AntibodyI used it in iWAT. I had strong and clean bands. I incubated the primary (1:1000) 3 hours at 37C and the secondary at room temperature for 50 min and i got nice results.
Date published: 2019-03-01
Rated 1 out of 5 by from no signalNo bands appear in WB analysis of mouse myoblasts.
Date published: 2018-10-03
Rated 5 out of 5 by from Good AntibodyWe got very good band using mouse cardiomyocyte sample. The band is very strong.
Date published: 2018-07-12
Rated 5 out of 5 by from Strong specific signalUsed at dilution 1:2500 after blocking with milk. Detects different variants of Mff in HeLa cel lysates. Clean strong signal without any apparent cross-reactivity.
Date published: 2017-07-04
Rated 5 out of 5 by from wonderfulThis product is great.I used it for a long time.This antibody is great for WB.
Date published: 2017-06-03
Rated 5 out of 5 by from excellent for wbit works well for wb in our lab, will purchase it in the future
Date published: 2017-02-20
Rated 5 out of 5 by from Nice antibody for MFF!This is a solid antibody, great IF staining and good detection in WB.
Date published: 2017-01-26
Rated 4 out of 5 by from We had no issues with this AB in our WesternWe had no issues with this AB in our Western.
Date published: 2015-08-28
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MFF 抗体 (B-2) is rated 4.4 out of 5 by 10.
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