matrin-3 Antibody (2539C3a): sc-81318

matrin-3 Antibody (2539C3a) is a mouse monoclonal IgG1 kappa light chain antibody that detects matrin-3 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). anti-matrin-3 antibody (2539C3a) is available as a non-conjugated format. matrin-3 protein is a crucial nuclear matrix component that contains one matrin-type zinc finger and two RNA recognition motif (RRM) domains, which are essential for RNA processing and gene expression regulation. Located primarily in the nucleus, matrin-3 is involved in the formation of the internal fibrogranular network, which provides structural support for nuclear architecture. matrin-3 is particularly important for nuclear retention of defective RNAs, as matrin-3 interacts with the PSF-p54/NRB heteromer complex, thereby preventing the accumulation of faulty transcripts that could lead to cellular dysfunction. Additionally, matrin-3 serves as a substrate for protein kinase A-mediated phosphorylation, which is a rapid signaling mechanism that conveys information from synapses containing NMDA receptors to neuronal nuclei, highlighting matrin-3′s role in synaptic plasticity and neuronal communication. Furthermore, the phosphorylation state of matrin-3 is critical, as phosphorylation may influence neuronal survival, with dysregulation potentially contributing to neurodegenerative processes. matrin-3 (2539C3a) antibody is an invaluable tool for researchers studying the intricate roles of matrin-3 in cellular processes and implications in various diseases.

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matrin-3 Antibody (2539C3a) References:

1. A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity.  |  Czarny-Ratajczak, M., et al. 2001. Am J Hum Genet. 69: 969-80. PMID: 11565064
2. Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death.  |  Giordano, G., et al. 2005. J Neurochem. 94: 808-18. PMID: 16000164
3. Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery.  |  De Angelis, PM., et al. 2006. Mol Cancer. 5: 20. PMID: 16709241
4. Bipartite nuclear localization signal of matrin 3 is essential for vertebrate cells.  |  Hisada-Ishii, S., et al. 2007. Biochem Biophys Res Commun. 354: 72-6. PMID: 17223080
5. Matrin 3 is a Ca2+/calmodulin-binding protein cleaved by caspases.  |  Valencia, CA., et al. 2007. Biochem Biophys Res Commun. 361: 281-6. PMID: 17658460
6. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.  |  Yu, LR., et al. 2007. J Proteome Res. 6: 4150-62. PMID: 17924679
7. Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain.  |  Belgrader, P., et al. 1991. J Biol Chem. 266: 9893-9. PMID: 2033075
8. Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells.  |  Niimori-Kita, K., et al. 2018. Sci Rep. 8: 13412. PMID: 30194346
9. Matrin-3 plays an important role in cell cycle and apoptosis for survival in malignant melanoma.  |  Kuriyama, H., et al. 2020. J Dermatol Sci. 100: 110-119. PMID: 32943284
10. The role of Matrin-3 in physiology and its dysregulation in disease.  |  Sprunger, ML. and Jackrel, ME. 2024. Biochem Soc Trans. 52: 961-972. PMID: 38813817
11. Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.  |  Cheng, X., et al. 2024. Mol Metab. 86: 101977. PMID: 38936659
12. Cloning and genomic mapping of the mouse matrin 3 gene and its pseudogenes.  |  Matsushima, Y., et al. 1998. Cytogenet Cell Genet. 81: 194-8. PMID: 9730601

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-matrin-3 Antibody (2539C3a) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-matrin-3 Antibody (2539C3a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

matrin-3 Antibody (2539C3a) Specifications

Alternate Product Name: matrin-3

Product Clone Name: 2539C3a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: matrin-3

Epitope Species: human

Product Reactivity/Detection: matrin-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for matrin-3 Antibody (2539C3a): N/A