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MAP-2 抗体 (C-2): sc-390543

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说明书
  • MAP-2抗体(C-2)是小鼠单克隆IgG1 κ, 在5篇文献中引用,规格为200 µg/ml
  • 与human的1754-1777氨基酸残基的MAP-2
  • 推荐用于 mouse, rat, human 和 来源的MAP-2A, MAP-2B and MAP-2C WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine, porcine and avian
  • 看 MAP-2 (A-4): sc-74421,可查看有标记的 MAP-2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是MAP-2 Antibody (C-2) for WB and IHC(P) applications. 的首选辅助检测试剂,这些试剂现与MAP-2 Antibody (C-2) 打包提供(请参阅下面的订购信息)。
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微管是细胞骨架网络的主要组成部分,与微管相关蛋白(MAP)相互作用。微管相关蛋白可分为结构和动态两类。结构微管相关蛋白包括MAP-1A、MAP-1B、MAP-2A、MAP-2B和MAP-2C,可刺激微管蛋白组装,增强微管稳定性,影响细胞内微管的空间分布。MAP-1和MAP-2均被认为是通过抑制微管的动态不稳定性来参与微管解聚的。MAP蛋白对微管动态不稳定的抑制被认为与MAP的磷酸化有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MAP-2 抗体 (C-2) 参考文献:

  1. 帕金森氏病黑质脑组织中神经元核和路易体中微管相关蛋白-2(MAP-2)免疫标记的异常模式。  |  D'Andrea, MR., et al. 2001. Neurosci Lett. 306: 137-40. PMID: 11406314
  2. MAP-2e是一种新型MAP-2异构体,在胶质瘤中表达,并描绘出肿瘤结构和浸润模式。  |  Suzuki, SO., et al. 2002. J Neuropathol Exp Neurol. 61: 403-12. PMID: 12025943
  3. 严重脑外伤幸存者血清MAP-2水平在6个月时升高,与预后改善相关。  |  Mondello, S., et al. 2012. Brain Inj. 26: 1629-35. PMID: 22794497
  4. MAP-2通过微管形成而过度表达,在癫痫大鼠的苔藓状纤维萌发中起着重要作用。  |  Tang, L., et al. 2014. J Mol Neurosci. 53: 103-8. PMID: 24390958
  5. 与阿尔茨海默氏症相关的淀粉样β肽被R28神经视网膜细胞内化,并破坏微管相关蛋白2(MAP-2)。  |  Taylor-Walker, G., et al. 2016. Exp Eye Res. 153: 110-121. PMID: 27751744
  6. MicroRNA miR-627-5p通过靶向MAP 2 K4和PI3K/AKT信号通路来抑制肺动脉平滑肌细胞功能障碍。  |  Li, T., et al. 2022. Genes Environ. 44: 23. PMID: 36163195
  7. 非神经细胞和组织中广泛存在与神经管相关蛋白(MAP-1和MAP-2)相关的多肽。  |  Wiche, G., et al. 1984. EMBO J. 3: 991-8. PMID: 6376120
  8. 微管相关蛋白MAP-1和MAP-2在大鼠脑神经元中的分布差异以及MAP-1与神经母细胞瘤细胞(克隆N2A)微管的关联。  |  Wiche, G., et al. 1983. EMBO J. 2: 1915-20. PMID: 6641705
  9. 人类微管相关蛋白2(MAP-2)的基因组结构以及MAP-2其他同工型的特征。  |  Kalcheva, N., et al. 1995. Proc Natl Acad Sci U S A. 92: 10894-8. PMID: 7479905
  10. MAP-2微管结合区与微管的非合作性结合。  |  Coffey, RL. and Purich, DL. 1995. J Biol Chem. 270: 1035-40. PMID: 7836356

订购信息

产品名称产品编号规格价格数量收藏夹

MAP-2 抗体 (C-2)

sc-390543
200 µg/ml
$322.00

MAP-2 (C-2): m-IgG Fc BP-HRP 套装

sc-540815
200 µg Ab; 10 µg BP
$361.00

MAP-2 (C-2): m-IgG1 BP-HRP 套装

sc-542389
200 µg Ab; 20 µg BP
$361.00

MAP-2 (C-2) 中和勝肽

sc-390543 P
100 µg/0.5 ml
$69.00

What application is the blocking peptide sc-390543 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
  • y_2026, m_10, d_22, h_6CST
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Rated 5 out of 5 by Germaine from Works as expected in WBThis MAP-2 monoclonal antibody works as expected in rat brain tissue extract at a 1:200 dilution
Date published: 2017-02-09
Rated 5 out of 5 by msabbir from Excellent antibody, highly recomended.This monoclonal antibody is very good, can detect multiple Map2 isoforms, I have seen a strong clean band in rat dorsal root ganglion neuron around 75kDa which seems to be Map2 isoform 2D. Clean band in western as well as 2D isoelectric focusing/SDS-PAGE. It also detected high molecular weight Map2A and 2B isoforms (>250kDa). Highly recommend this antibody.
Date published: 2017-02-01
Rated 5 out of 5 by JM from Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human cerebral cortex tissue. -SCBT QC
Date published: 2015-03-19
Rated 5 out of 5 by TO from Satisfactory Western Blot data of MAPSatisfactory Western Blot data of MAP-2 expression in non-transfected and human MAP-2 transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-05-30
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MAP-2 抗体 (C-2) is rated 5.0 out of 5 by 4.
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