LDLR Antibody (B-10): sc-373831
- LDLR Antibody (B-10) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 13-47 near the N-terminus of LDLR of human origin
- recommended for detection of LDLR of human origin by WB, IP, IF and ELISA
- See LDLR (C7): sc-18823 for LDLR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LDLR Antibody (B-10) for WB applications. These reagents are now offered in bundles with LDLR Antibody (B-10) (see ordering information below).
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SEE ALSO...
LDLR Antibody (B-10) is a mouse monoclonal IgG2b antibody that detects low density lipoprotein receptor (LDLR) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LDLR antibody (B-10) plays a crucial role in understanding the function of LDLR, which is essential for mediating the uptake of low density lipoprotein (LDL) and its subsequent degradation in lysosomes, thereby providing cholesterol to cells. This process is vital for maintaining cellular cholesterol homeostasis and overall lipid metabolism. LDLR (B-10) antibody enables researchers to study the LDL receptor located on the cell surface as a transmembrane protein, where the cytoplasmic domain is critical for clustering in coated pits, facilitating rapid endocytosis of bound LDL. Dysregulation or mutations in the LDLR gene can lead to familial hypercholesterolemia, a genetic disorder characterized by elevated cholesterol levels and an increased risk of premature coronary atherosclerosis. LDLR monoclonal antibody (B-10) helps researchers gain insights into the mechanisms of cholesterol uptake and the implications of LDLR dysfunction in cardiovascular diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LDLR Antibody (B-10) | sc-373831 | 200 µg/ml | $322.00 | |||
LDLR Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-535317 | 200 µg Ab; 40 µg BP | $361.00 | |||
LDLR Antibody (B-10): m-IgG2b BP-HRP Bundle | sc-549392 | 200 µg Ab; 10 µg BP | $361.00 |