Date published: 2025-9-7

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LCOR 抗体 (C-6): sc-377019

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说明书
  • LCOR 抗体 C-6 是小鼠单克隆 IgG1 κ,LCOR抗体, 在1篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列87-281位于human物种的LCOR的内部区域内
  • LCOR 抗体 (C-6) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 LCOR; 也和以下物种反应,包括: bovine
  • 抗LCOR抗体(C-6)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取LCOR (C-6): sc-377019免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 LCOR 抗体 (C-6) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与LCOR 抗体 (C-6) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

LCOR抗体(C-6)是一种IgG1 κ小鼠单克隆LCOR抗体(也称为LCOR抗体),可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的LCOR蛋白。LCOR抗体(C-6)既可作为非偶联的抗LCOR抗体形式提供,也可作为多种偶联形式的抗LCOR抗体提供,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。LCOR(配体依赖性共抑制因子),也被称为MLR2,是一个包含433个氨基酸的转录共抑制因子,具有一个LXXLL基序、一个核定位信号和一个螺旋-环-螺旋结构域。LCOR在胎儿和成人组织中广泛表达,并通过其LXXLL基序被招募到核受体。在雌二醇存在的情况下,LCOR与几种雌激素受体相互作用,如ERα和ERβ。此外,LCOR作为分子支架,招募参与转录抑制的蛋白质到DNA。LCOR的活性以受体依赖性的方式被HDAC(组蛋白去乙酰化酶)抑制剂曲古抑菌素A所抑制,这表明其依赖于HDAC的作用模式。LCOR在一个负反馈环中发挥作用,以减少激素诱导的反式激活。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LCOR 抗体 (C-6) 参考文献:

  1. 配体依赖性核受体核心抑制因子 LCoR 通过组蛋白去乙酰化酶依赖性和非依赖性机制发挥作用。  |  Fernandes, I., et al. 2003. Mol Cell. 11: 139-50. PMID: 12535528
  2. 与激动剂结合的核受体:不仅仅是辅激活剂的目标。  |  Fernandes, I. and White, JH. 2003. J Mol Endocrinol. 31: 1-7. PMID: 12914520
  3. 核心加压素在核荷尔蒙受体转录调控中的作用。  |  Privalsky, ML. 2004. Annu Rev Physiol. 66: 315-60. PMID: 14977406
  4. 激动剂结合的核受体招募核心抑制因子  |  White, JH., et al. 2004. Vitam Horm. 68: 123-43. PMID: 15193453
  5. 作为核受体功能介质的共激活因子和核心加压因子:最新进展。  |  Jenster, G. 1998. Mol Cell Endocrinol. 143: 1-7. PMID: 9806345

订购信息

产品名称产品编号规格价格数量收藏夹

LCOR 抗体 (C-6)

sc-377019
200 µg/ml
$316.00

LCOR (C-6): m-IgG Fc BP-HRP 套装

sc-527573
200 µg Ab; 10 µg BP
$354.00

LCOR (C-6): m-IgG1 BP-HRP 套装

sc-532946
200 µg Ab; 20 µg BP
$354.00

LCOR 抗体 (C-6) AC

sc-377019 AC
500 µg/ml, 25% agarose
$416.00

LCOR 抗体 (C-6) HRP

sc-377019 HRP
200 µg/ml
$316.00

LCOR 抗体 (C-6) FITC

sc-377019 FITC
200 µg/ml
$330.00

LCOR 抗体 (C-6) PE

sc-377019 PE
200 µg/ml
$343.00

LCOR 抗体 (C-6) Alexa Fluor® 488

sc-377019 AF488
200 µg/ml
$357.00

LCOR 抗体 (C-6) Alexa Fluor® 546

sc-377019 AF546
200 µg/ml
$357.00

LCOR 抗体 (C-6) Alexa Fluor® 594

sc-377019 AF594
200 µg/ml
$357.00

LCOR 抗体 (C-6) Alexa Fluor® 647

sc-377019 AF647
200 µg/ml
$357.00

LCOR 抗体 (C-6) Alexa Fluor® 680

sc-377019 AF680
200 µg/ml
$357.00

LCOR 抗体 (C-6) Alexa Fluor® 790

sc-377019 AF790
200 µg/ml
$357.00

Can LCOR (C-6): sc-377019 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Randy McDonald
Thank you for your question. Yes, LCOR (C-6): sc-377019 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-25
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Rated 2 out of 5 by from WBLcor (c-6) did not work for mouse Plasenta WB. We used anti-mouse IgG1 as the secondary antibody.
Date published: 2018-03-28
Rated 1 out of 5 by from too much bonds for 4t1 celltoo much bonds to detect mouse 4t1 cell line, cannot tell which is lcor.
Date published: 2017-10-12
Rated 4 out of 5 by from Anti Lcor antibodyIt is great for immunoprecipitation. At 0.8ug (4ul) it IP-ed a good amount of the protein.
Date published: 2017-09-02
Rated 1 out of 5 by from a lot of signal in cytoplasm for a nuclear proteinThis Ab has a lot of unspecific signal in the cytoplasm of mouse breast cancer cell lines. The signal of this Ab does not overlap the one of the rabbit polyclonal Ab anti-LCOR,which we used for previous publication, which is even not anymore available. really disappointing.
Date published: 2017-06-27
Rated 5 out of 5 by from Produced superb immunoperoxidase cytoplasmicProduced superb immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human kidney tissue. -SCBT QC
Date published: 2015-05-06
Rated 5 out of 5 by from Produced positive Western Blot data of LCORProduced positive Western Blot data of LCOR expression in non-transfected and human LCOR transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-10-21
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LCOR 抗体 (C-6) is rated 3.0 out of 5 by 6.
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