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L-type Ca++ CP α1S 抗体 (IIC12D4): sc-21781

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说明书
  • L-type Ca++ CP alpha 1S 抗体 IIC12D4 是小鼠单克隆 IgG1 κ,L-type Ca++ CP α1S抗体, 在2篇文献中引用,规格为200 µg/ml
  • 针对 rabbit 骨骼肌三联体
  • 推荐用于 mouse, rat, human 和 rabbit 来源的170 kDa, L-type calcium channel α1S WB, IP 和 IF检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是L-type Ca++ CP α1S Antibody (IIC12D4) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与L-type Ca++ CP α1S Antibody (IIC12D4) 打包提供(请参阅下面的订购信息)。

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関連項目

L型钙离子通道α1S抗体(IIC12D4)是一种小鼠单克隆IgG1κ轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和免疫荧光(IF)检测小鼠、大鼠、人类和兔源的L型钙离子通道α1S蛋白。抗L型钙离子通道α1S抗体(IIC12D4)以非结合形式提供。L型钙离子通道在调节钙离子进入兴奋性细胞方面起着至关重要的作用,而钙离子进入兴奋性细胞对于肌肉收缩、激素分泌和神经递质释放等各种生理过程至关重要。这些通道由一个复杂的结构组成,其中包括一个形成通道孔的α-1亚基,以及调节通道活性和药理特性的辅助亚基。α-1S亚基对于骨骼肌的兴奋收缩耦合至关重要,因为它直接影响肌浆网中钙的释放,从而引发肌肉收缩。此外,L型钙通道可与多种信号分子相互作用,包括G蛋白偶联受体,从而增强细胞信号通路中的调节能力和特异性。这种复杂的相互作用凸显了L型钙离子通道α1S蛋白在维持细胞功能和响应生理需求方面的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

L-type Ca++ CP α1S 抗体 (IIC12D4) 参考文献:

  1. 钙离子通道1.1控制着调节成人骨骼肌可塑性的频率依赖性事件。  |  Jorquera, G., et al. 2013. J Cell Sci. 126: 1189-98. PMID: 23321639
  2. CaV1.1与其远端C端之间似乎不存在物理或功能上的相互作用。  |  Ohrtman, JD., et al. 2015. J Gen Physiol. 145: 303-14. PMID: 25779869
  3. 电压门控钙通道Cav1.1复合物的结构。  |  Wu, J., et al. 2015. Science. 350: aad2395. PMID: 26680202
  4. 表达与肌萎缩侧索硬化症相关的1型Cu/Zn超氧化物歧化酶(G93A)突变体的小鼠骨骼肌中,CaV1.1的功能逐渐受损。  |  Beqollari, D., et al. 2016. Skelet Muscle. 6: 24. PMID: 27340545
  5. 缺乏RYR1或Cav1.1的E14.5小鼠骨骼肌在E18.5时出现明显的转录组变化。  |  Filipova, D., et al. 2018. PLoS One. 13: e0194428. PMID: 29543863
  6. 与HypoPP相关的钙离子通道1.1域III突变体中存在门控孔电流。  |  Wu, F., et al. 2021. J Gen Physiol. 153: PMID: 34463712
  7. 骨骼肌钙离子通道1.1通道的四个电压传感器在电压依赖性激活中具有不同的作用。  |  Savalli, N., et al. 2021. J Gen Physiol. 153: PMID: 34546289
  8. 钙离子通道1.1的电压感应结构域具有不同的作用。  |  Short, B. 2021. J Gen Physiol. 153: PMID: 34623381
  9. 在骨骼肌的兴奋-收缩和兴奋-转录耦合过程中,泛素蛋白激酶-1和钙离子通道1.1表现出相互影响。  |  Jaque-Fernández, F., et al. 2021. J Gen Physiol. 153: PMID: 34636893
  10. γ1亚基对钙电流的调节取决于CaV1.1的替代剪接。  |  El Ghaleb, Y., et al. 2022. J Gen Physiol. 154: PMID: 35349630

订购信息

产品名称产品编号规格价格数量收藏夹

L-type Ca++ CP α1S 抗体 (IIC12D4)

sc-21781
200 µg/ml
$316.00

L-type Ca++ CP α1S (IIC12D4): m-IgG Fc BP-HRP 套装

sc-536672
200 µg Ab; 10 µg BP
$354.00

L-type Ca++ CP α1S (IIC12D4): m-IgGκ BP-HRP 套装

sc-533831
200 µg Ab; 40 µg BP
$354.00

L-type Ca++ CP α1S (IIC12D4): m-IgG1 BP-HRP 套装

sc-544754
200 µg Ab; 20 µg BP
$354.00

What is the recommended starting dilution for Western blot for L-type Ca++ CP α1S (IIC12D4): sc-21781 monoclonal antibody?

Asked by: Trav11
Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link: https://datasheets.scbt.com/sc-21781.pdf If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Technical Support
Date published: 2017-02-27

hello, i want to know whether this antibody is good in immunostaining? Is it possible to get some to try it? thanks a lot.

Asked by: JoeJia
Thank you very much for your inquiry. We recommend the L-type Ca++ CP α1S Antibody (IIC12D4): sc-21781 for detection of 170 kDa, L-type calcium channel α1S of mouse, rat, human and rabbit origin by WB, IP and IF, which comprises immunocytochemistry on methanol-fixed cells as well as immunohistochemistry on acetone-fixed, cryo-sections at a starting dilution of 1:50 - 1:100. We do not provide any trial sizes of this antibody, but we do offer a product warranty. In case you should experience any difficulties with one of our products, please contact our technical service immediately.
Answered by: Technical Support Europe
Date published: 2017-01-11
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Rated 4 out of 5 by from Robust signal in WB in rat skeletal muscleRobust signal in WB in rat skeletal muscle tissue extract. -SCBT QC
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L-type Ca ++ CP α1S 抗体 (IIC12D4) is rated 4.0 out of 5 by 1.
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