L-type Ca⁺⁺ CP α1C Antibody (D-6): sc-398433

L-type Ca++ CP α1C Antibody (D-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects L-type Ca++ CP α1C of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-L-type Ca++ CP α1C antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. L-type Ca++ CP α1C plays a crucial role in mediating calcium entry into excitable cells, which is essential for processes such as muscle contraction, hormone secretion, and neurotransmitter release. L-type Ca++ CP α1C is primarily located in the plasma membrane of excitable cells, where L-type Ca++ CP α1C forms part of a complex that includes an α-1 subunit, an intracellular β-subunit, a disulfide-linked α-2/δ subunit, and a transmembrane γ-subunit. The localization of L-type calcium channels at the cell membrane allows for rapid and efficient calcium influx in response to membrane depolarization, thereby triggering various physiological responses. These channels can interact with G protein-coupled receptors, forming macromolecular signaling complexes that enhance the specificity of calcium signaling pathways. L-type Ca++ CP α1C′s ability to initiate critical cellular functions underscores its importance in both normal physiology and potential pathophysiological conditions.

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L-type Ca⁺⁺ CP α1C Antibody (D-6) References:

1. Structure and regulation of voltage-gated Ca2+ channels.  |  Catterall, WA. 2000. Annu Rev Cell Dev Biol. 16: 521-55. PMID: 11031246
2. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.  |  Davare, MA., et al. 2001. Science. 293: 98-101. PMID: 11441182
3. A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.  |  Barg, S., et al. 2002. Diabetes. 51 Suppl 1: S74-82. PMID: 11815462
4. L-type Ca2+ channels of the embryonic mouse heart.  |  Klugbauer, N., et al. 2002. Eur J Pharmacol. 447: 279-84. PMID: 12151019
5. CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype.  |  Busquet, P., et al. 2010. Int J Neuropsychopharmacol. 13: 499-513. PMID: 19664321
6. Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels.  |  Striessnig, J., et al. 2010. Pflugers Arch. 460: 361-74. PMID: 20213496
7. Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels.  |  Oliveria, SF., et al. 2012. J Neurosci. 32: 15328-37. PMID: 23115171
8. Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells.  |  Tang, G., et al. 2013. Diabetologia. 56: 533-41. PMID: 23275972
9. New aspects in cardiac L-type Ca2+ channel regulation.  |  Pallien, T. and Klussmann, E. 2020. Biochem Soc Trans. 48: 39-49. PMID: 32065210
10. Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics.  |  Gross, P., et al. 2021. Circ Res. 128: 92-114. PMID: 33092464
11. Molecular biology of calcium channels.  |  Perez-Reyes, E. and Schneider, T. 1995. Kidney Int. 48: 1111-24. PMID: 8569073
12. The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?  |  Randall, AD. 1998. J Membr Biol. 161: 207-13. PMID: 9493126

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-L-type Ca⁺⁺ CP α1C Antibody (D-6) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-L-type Ca⁺⁺ CP α1C Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

L-type Ca⁺⁺ CP α1C Antibody (D-6) Specifications

Alternate Product Name: L-type Ca++ CP α1C

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1721-2000

Epitope Target: L-type Ca⁺⁺ CP α1C

Epitope Species: human

Product Reactivity/Detection: L-type Ca⁺⁺ CP α1C

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for L-type Ca⁺⁺ CP α1C Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin