Date published: 2025-9-9

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Krs-2 抗体 (H-8): sc-515051

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说明书
  • Krs-2 抗体 H-8 是小鼠单克隆 IgG2a κ,Krs-2抗体, 在5篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列291-355位于human物种的Krs-2的内部区域内
  • Krs-2 抗体 (H-8) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Krs-2
  • 抗Krs-2抗体(H-8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Krs-2 (H-8): sc-515051免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是Krs-2 Antibody (H-8) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Krs-2 Antibody (H-8) 打包提供(请参阅下面的订购信息)。

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関連項目

Krs-2抗体(H-8)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的Krs-2蛋白。Krs-2 (H-8) 抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。Krs-2,也称为MST-1,在细胞信号传导通路中发挥着关键作用,尤其是在激活细胞分裂原活化蛋白激酶(MAPK)级联反应方面,该级联反应可调节细胞增殖、分化及凋亡等过程。Krs-2是半胱天冬酶-3的直接底物,参与影响细胞存活和死亡的凋亡信号通路。Krs-2能够调节这些通路,这凸显了它在正常生理过程和癌症等疾病中的重要性,因为凋亡失调会导致肿瘤形成。使用抗Krs-2抗体(H-8)能够使研究人员深入了解这种蛋白质的功能动态和生物学意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Krs-2 抗体 (H-8) 参考文献:

  1. 鉴定受 cAMP 依赖性蛋白激酶调控的哺乳动物 STE20 样激酶 3 的人脑特异性同工酶。  |  Zhou, TH., et al. 2000. J Biol Chem. 275: 2513-9. PMID: 10644707
  2. 酵母 Cdc42 GTPase 和 Ste20 PAK 样激酶调控 Sho1 依赖性激活 Hog1 MAPK 通路。  |  Raitt, DC., et al. 2000. EMBO J. 19: 4623-31. PMID: 10970855
  3. MST 是一种生理性的 caspase 底物,在 caspase 激活的上游和下游都能高度敏化细胞凋亡。  |  Lee, KK., et al. 2001. J Biol Chem. 276: 19276-85. PMID: 11278283
  4. MST4,一种新的 Ste20 相关激酶,通过调节 ERK 通路介导细胞生长和转化。  |  Lin, JL., et al. 2001. Oncogene. 20: 6559-69. PMID: 11641781
  5. 蛋白激酶同源物 Ste20p 是将酵母信息素反应 G 蛋白 beta gamma 亚基与下游信号元件连接起来所必需的。  |  Leberer, E., et al. 1992. EMBO J. 11: 4815-24. PMID: 1464311
  6. 肾细胞癌中 AIF 的下调及其与 STK3 的相互作用  |  Xu, S., et al. 2014. PLoS One. 9: e100824. PMID: 24992339
  7. Hippo激酶STK3/STK4对LC3的磷酸化对于自噬至关重要。  |  Wilkinson, DS., et al. 2015. Mol Cell. 57: 55-68. PMID: 25544559
  8. 脂肪细胞中的STK3/STK4信号传导可调节线粒体自噬和能量消耗。  |  Cho, YK., et al. 2021. Nat Metab. 3: 428-441. PMID: 33758424
  9. 丝氨酸/苏氨酸蛋白激酶-3通过激活Ras-MAPK介导的细胞周期进展促进口腔鳞状细胞癌的发生。  |  Yue, L., et al. 2023. Int J Gen Med. 16: 3115-3124. PMID: 37496599
  10. STK3激酶激活可通过FOXO1-TP53INP1/P21途径抑制食管鳞状细胞癌的肿瘤增生。  |  Zhao, Z., et al. 2024. Cell Oncol (Dordr). 47: 1295-1314. PMID: 38436783
  11. 探索STK3在黑色素瘤中的作用:信号传导网络和治疗机会的系统性回顾。  |  Khanahmadi, M., et al. 2024. Mol Biol Rep. 52: 8. PMID: 39576434
  12. 具有不寻常辅助因子要求的人 STE20 样蛋白激酶的克隆和表征。  |  Schinkmann, K. and Blenis, J. 1997. J Biol Chem. 272: 28695-703. PMID: 9353338

订购信息

产品名称产品编号规格价格数量收藏夹

Krs-2 抗体 (H-8)

sc-515051
200 µg/ml
$316.00

Krs-2 (H-8): m-IgG Fc BP-HRP 套装

sc-531275
200 µg Ab; 10 µg BP
$354.00

Krs-2 (H-8): m-IgGκ BP-HRP 套装

sc-524918
200 µg Ab, 40 µg BP
$354.00

Krs-2 (H-8): m-IgG2a BP-HRP 套装

sc-547748
200 µg Ab; 10 µg BP
$354.00

Krs-2 抗体 (H-8) AC

sc-515051 AC
500 µg/ml, 25% agarose
$416.00

Krs-2 抗体 (H-8) HRP

sc-515051 HRP
200 µg/ml
$316.00

Krs-2 抗体 (H-8) FITC

sc-515051 FITC
200 µg/ml
$330.00

Krs-2 抗体 (H-8) PE

sc-515051 PE
200 µg/ml
$343.00

Krs-2 抗体 (H-8) Alexa Fluor® 488

sc-515051 AF488
200 µg/ml
$357.00

Krs-2 抗体 (H-8) Alexa Fluor® 546

sc-515051 AF546
200 µg/ml
$357.00

Krs-2 抗体 (H-8) Alexa Fluor® 594

sc-515051 AF594
200 µg/ml
$357.00

Krs-2 抗体 (H-8) Alexa Fluor® 647

sc-515051 AF647
200 µg/ml
$357.00

Krs-2 抗体 (H-8) Alexa Fluor® 680

sc-515051 AF680
200 µg/ml
$357.00

Krs-2 抗体 (H-8) Alexa Fluor® 790

sc-515051 AF790
200 µg/ml
$357.00

I need to use an antibody to detect the protein in samples of canine origin. Do you know if Krs-2 (H-8): sc-515051 mouse monoclonal antibody will work?

Asked by: Cweed
Thank you for your inquiry. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity. We are available by phone, e-mail or chat.
Answered by: Technical Support
Date published: 2017-02-28
  • y_2025, m_8, d_27, h_5CST
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Rated 5 out of 5 by from Good for Western blotAntibody works for Western blot with HepG2 cell lysate in published research. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from wonderful antibody1:200 diluted for wb of rat protein ,the band is quite strong and special!wonderful
Date published: 2018-01-24
Rated 5 out of 5 by from suitable for WBI used it for WB in HCC cell line PLC/PRF/5 and the result shown a very clear single band
Date published: 2017-03-28
Rated 5 out of 5 by from Excellent antibody for Western blotting.This product has been independently tested and validated in-house at Kinexus Bioinformatics Corporation as a very potent and highly specific antibody for Western blotting with a mixture of mouse brain, testes and thymus tissue lysates. It strongly detects an appropriately sized ~56 kDa target protein in immunoblots as well as an unidentified ~36 kDa cross-reactive protein.
Date published: 2016-10-13
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Krs-2 抗体 (H-8) is rated 5.0 out of 5 by 4.
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