Date published: 2025-9-6

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KIF2C 抗体 (2488C3a): sc-81305

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说明书
  • KIF2C 抗体 2488C3a 是小鼠单克隆 IgG1 κ,KIF2C抗体, 在10篇文献中引用,规格为100 µg/ml
  • 针对与human KIF2C N-terminus附近区域相对应的重组蛋白
  • 推荐用于 human 来源的KIF2C WB, IP, IF 和 FCM检测
  • 关于如何获取KIF2C (2488C3a): sc-81305免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是KIF2C Antibody (2488C3a) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与KIF2C Antibody (2488C3a) 打包提供(请参阅下面的订购信息)。

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関連項目

KIF2C抗体(2488C3a)是一种IgG1κ小鼠单克隆KIF2C抗体(也称为MCAK抗体),可通过WB、IP、IF和FCM检测人源的KIF2C蛋白。KIF2C抗体(2488C3a)可作为非偶联抗KIF2C抗体使用。驱动蛋白家族成员2c(KIF2C),也被称为有丝分裂着丝粒相关驱动蛋白(MCAK),是驱动蛋白样蛋白家族的一员。KIF2C是一种细胞质和核蛋白,存在于整个细胞周期中。KIF2C在有丝分裂前期早期与着丝粒结合,并在有丝分裂后期解离。KIF2C在胸腺和睾丸中含量丰富,在小肠、结肠黏膜和胎盘中含量较低。人类KIF2C定位于1p34.1染色体上。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

KIF2C 抗体 (2488C3a) 参考文献:

  1. 驱动蛋白相关蛋白 MCAK 是一种微管解聚酶,可在微管末端形成 ATP-水解复合物。  |  Hunter, AW., et al. 2003. Mol Cell. 11: 445-57. PMID: 12620232
  2. 中心粒 MCAK 的缺失会导致染色体连接和分离缺陷,这是由于着丝点连接不当造成的。  |  Kline-Smith, SL., et al. 2004. Mol Biol Cell. 15: 1146-59. PMID: 14699064
  3. MCAK 与聚合微管的尖端结合。  |  Moore, AT., et al. 2005. J Cell Biol. 169: 391-7. PMID: 15883193
  4. 驱动蛋白-13 蛋白 Kif2a, Kif2b 和 Kif2c/MCAK 在人类细胞有丝分裂过程中具有不同的作用。  |  Manning, AL., et al. 2007. Mol Biol Cell. 18: 2970-9. PMID: 17538014
  5. 驱动蛋白家族成员 2C/有丝分裂中心粒相关驱动蛋白的过表达参与了乳腺癌的发生。  |  Shimo, A., et al. 2008. Cancer Sci. 99: 62-70. PMID: 17944972
  6. MCAK 与 EB1 有联系。  |  Lee, T., et al. 2008. Oncogene. 27: 2494-500. PMID: 17968321
  7. MCAK 通过促进着丝点微管的周转来促进染色体的移动。  |  Wordeman, L., et al. 2007. J Cell Biol. 179: 869-79. PMID: 18039936
  8. KIF2C通过激活JAK2/STAT3信号通路促进透明细胞肾细胞癌的进展。  |  Deng, H., et al. 2023. Mol Cell Probes. 72: 101938. PMID: 37863123
  9. KIF2C:肿瘤发生中信号通路、免疫浸润和DNA损伤修复的重要因子。  |  Li, RQ., et al. 2024. Biomed Pharmacother. 171: 116173. PMID: 38237349
  10. KIF2C/MCAK是一种预后生物标志物,其在恶性肿瘤进展和癌症患者预后中的致癌潜力:作为生物标志物的系统评价和荟萃分析。  |  Kreis, NN., et al. 2024. Crit Rev Clin Lab Sci. 61: 404-434. PMID: 38344808
  11. 人类有丝分裂中心粒相关驱动蛋白基因的克隆与表达。  |  Kim, IG., et al. 1997. Biochim Biophys Acta. 1359: 181-6. PMID: 9434124
  12. 有丝分裂中心粒相关驱动蛋白对无丝分裂期染色体分离非常重要。  |  Maney, T., et al. 1998. J Cell Biol. 142: 787-801. PMID: 9700166

订购信息

产品名称产品编号规格价格数量收藏夹

KIF2C 抗体 (2488C3a)

sc-81305
100 µg/ml
$333.00

KIF2C (2488C3a): m-IgG Fc BP-HRP 套装

sc-537243
100 µg Ab; 10 µg BP
$354.00

KIF2C (2488C3a): m-IgGκ BP-HRP 套装

sc-534466
100 µg Ab; 40 µg BP
$354.00

KIF2C (2488C3a): m-IgG1 BP-HRP 套装

sc-545099
100 µg Ab; 20 µg BP
$354.00

What is the recommended storage condition for KIF2C (2488C3a): sc-81305?

Asked by: Trav11
Thank you for your question. We recommend storing the antibody at 4° C.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Great antibodyI got a sample for test. It has very nice signal in western Blot.
Date published: 2019-04-22
Rated 5 out of 5 by from WB 1:50比例稀释,条带很sharp做WB条带很好。非常sharp,稳定性也很好,稀释比例1:50,反复用了很久,免疫组化出图不是特别好,可能是抗体浓度不够
Date published: 2018-07-06
Rated 4 out of 5 by from Good for IFThis KIF2C Antibody (2488C3a) shows strong specific signal in IF staining in primary rat motor neuron.
Date published: 2018-02-20
Rated 5 out of 5 by from a fantastic antibodyThis antibody recognizes a very clear and strong band of predicted M.W. on the western blot (1:500 dilution, 40 ug U251 lysate). It probably works well for IF, too (giving nuclear staining as shown by other antibodies) (1:200 dilution, formaldehyde-fixed HeLa).
Date published: 2017-08-28
Rated 5 out of 5 by from Reliable Antibody, Great for WBThis antibody works well in WB, strong signal and no background. Highly recommend.
Date published: 2017-01-17
Rated 5 out of 5 by from Very good and strong band in WB for differentVery good and strong band in WB for different cell lines; also robust and specific staining in IF.
Date published: 2015-09-23
Rated 5 out of 5 by from Positive band in WB in KPositive band in WB in K-562 and Ramos whole cell lysates. -SCBT QC
Date published: 2015-06-23
Rated 5 out of 5 by from Robust signal in WB in 293T whole cell lysateRobust signal in WB in 293T whole cell lysate and HeLa nuclear extract. -SCBT QC
Date published: 2015-03-05
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KIF2C 抗体 (2488C3a) is rated 4.9 out of 5 by 11.
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