Integrin β4/ITGB4/CD104 Antibody (B-4): sc-377523

Integrin β4 Antibody (B-4) is a mouse monoclonal IgG2a antibody that detects Integrin β4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin β4, also known as CD104, is a crucial component of the integrin family, consisting of 1,822 amino acids and functioning as a single-pass type I membrane protein. Anti-Integrin β4 antibody (B-4) recognizes a protein that plays a vital role in cell adhesion and signaling, primarily by serving as a receptor for Laminin, which is essential for maintaining the structural integrity of epithelial tissues. The interaction between Integrin β4 and Laminin is critical for processes such as cell migration, differentiation, and tissue repair, highlighting its importance in both normal physiological functions and pathological conditions, including cancer metastasis. Integrin β4 exists in five alternatively spliced isoforms, all encoded by a gene located on human chromosome 17q25.1, which adds complexity to its functional roles in various cellular contexts. With its ability to interact with other proteins and influence cellular behavior, Integrin β4 is a significant target for research in cell biology and therapeutic development. Integrin β4 (B-4) antibody serves as an invaluable tool for researchers aiming to explore the intricate mechanisms of cell adhesion and signaling pathways in human tissues.

The preferred Integrin β4/ITGB4/CD104 antibody is Integrin β4/ITGB4/CD104 Antibody (A9): sc-13543.