IKK beta Antibody (10A9B6): sc-56918
- IKKβ Antibody (10A9B6) is a mouse monoclonal IgG1, cited in 4 publications, provided at 100 µg/ml
- raised against full length IKKβ of human origin
- recommended for detection of IKKβ of human origin by WB, IP and ELISA
- See IKKβ (H-4): sc-8014 for IKKβ antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IKKβ Antibody (10A9B6). This work is in progress.
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IKKβ Antibody (10A9B6) is a mouse monoclonal IgG1 antibody that detects IKKβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IKKβ, a key component of the IKK complex, plays a crucial role in the activation of the transcription factor NFκB, which is essential for regulating immune responses, inflammation, and cell survival. Located primarily in the cytoplasm, IKKβ interacts with IκB proteins, facilitating their phosphorylation and subsequent degradation, which allows NFκB to translocate to the nucleus and initiate the transcription of target genes. The proper functioning of IKKβ is vital, as dysregulation can lead to various diseases, including cancer and autoimmune disorders. Additionally, IKKβ undergoes post-translational modifications, such as phosphorylation, which can influence activity and interactions with other proteins, further underscoring importance in cellular signaling pathways. Anti-IKKβ antibody (10A9B6) is an invaluable tool for researchers studying NFκB signaling and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IKK beta Antibody (10A9B6) References:
- Signal-induced ubiquitination of I kappaB Kinase-beta. | Carter, RS., et al. 2003. J Biol Chem. 278: 48903-6. PMID: 14514672
- IKK{beta} as a target for treatment of inflammation induced bone loss. | Ruocco, MG. and Karin, M. 2005. Ann Rheum Dis. 64 Suppl 4: iv81-5. PMID: 16239395
- PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase. | Agarwal, NK., et al. 2014. Oncotarget. 5: 815-23. PMID: 24553260
- IKKβ slows Huntington's disease progression in R6/1 mice. | Ochaba, J., et al. 2019. Proc Natl Acad Sci U S A. 116: 10952-10961. PMID: 31088970
- IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells. | Peng, X., et al. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 118857. PMID: 32949647
- Enhanced Tendon-to-Bone Healing via IKKβ Inhibition in a Rat Rotator Cuff Model. | Golman, M., et al. 2021. Am J Sports Med. 49: 780-789. PMID: 33507808
- IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington disease mouse model. | Soylu-Kucharz, R., et al. 2022. iScience. 25: 103771. PMID: 35146388
- Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth. | Napoleon, JV., et al. 2022. Proc Natl Acad Sci U S A. 119: e2115071119. PMID: 35476515
- IKKβ increases neuropilin-2 and promotes the inhibitory function of CD9+ Bregs to control allergic diseases. | Wang, Y., et al. 2022. Pharmacol Res. 185: 106517. PMID: 36265554
- Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth. | Rao, S., et al. 2023. Am J Physiol Lung Cell Mol Physiol. 325: L299-L313. PMID: 37310763
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKKβ Antibody (10A9B6) | sc-56918 | 100 µg/ml | $339.00 |